TY -的T1的影响采用2017年全球肺功能行动参考方程解释一氧化碳转移因子JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01905 -2019欧元SP - 1901905 AU Brazzale丹尼·J . AU - Seccombe利m . AU -威尔士,利亚姆AU - Lanteri,西莉亚j . AU -法拉,克劳德·s . AU - Ruehland沃伦·r·Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/02/26/13993003.01905 - 2019. -抽象N2 -肺功能最近发布的全球倡议(GLI)一氧化碳转移因子(TLCO)采用电流参考方程提供了一个机会,全龄,广泛适用的参考集。本研究的目的是为了证明由常用参考方程转换为GLI对TLCO结果解释的影响。对来自澳大利亚三所教学医院临床肺功能实验室的33 863例TLCO结果(48%女性，88%白人，n=930<18 y)进行分析。采用GLI等常用参考方程计算正常下限(LLN)及TLCO低于此值的患者比例。GLI的平均TLCO LLN与其他方程相似或更低，Crapo方程的差异最大(中位数:−1.25,IQR:−1.64,0.86 mmol·min−1·kPa−1)。这些差异导致GLI中TLCO减少率的改变，尤其是成人(+1.9% vs Miller - - 27.6% vs Crapo)，而儿童(- 0.8% vs Kim - - 14.2% vs Cotes)的变化更大。对于成人，GLI的原始一致性最高的是Miller方程(94.7%)，而对于儿童，是Kim方程(98.1%)。对年轻人和成年女性的结果进行了从异常到正常的重新分类，尤其是从Roca方程到GLI方程(女性占30%，男性占16%)。在成人中采用GLI TLCO参考方程将导致不同的解释，这取决于以前使用的方程，在更大程度上在成年女性中。 The effect on interpretation in children is less significant.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Mr. Brazzale has nothing to disclose.Conflict of interest: Dr. Seccombe has nothing to disclose.Conflict of interest: Dr. Welsh has nothing to disclose.Conflict of interest: Dr. Lanteri has nothing to disclose.Conflict of interest: Dr. Farah has nothing to disclose.Conflict of interest: Dr. Ruehland has nothing to disclose. ER -