TY -的T1的影响采用全球肺Function Initiative 2017 reference equations on the interpretation of carbon monoxide transfer factor JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01905-2019 SP - 1901905 AU - Brazzale, Danny J. AU - Seccombe, Leigh M. AU - Welsh, Liam AU - Lanteri, Celia J. AU - Farah, Claude S. AU - Ruehland, Warren R. Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/02/26/13993003.01905-2019.abstract N2 - The recently published Global Lung Function Initiative (GLI) carbon monoxide transfer factor (TLCO) reference equations provide an opportunity to adopt a current, all-age, widely applicable reference set. The aim of this study was to document the effect of changing to GLI from commonly utilised reference equations on the interpretation of TLCO results.33 863 TLCO results (48% female, 88% Caucasian, n=930<18 y) from clinical pulmonary function laboratories within three Australian teaching hospitals were analysed. The lower limit of normal (LLN) and proportion of patients with a TLCO below this value were calculated using GLI and other commonly used reference equations.The average TLCO LLN for GLI was similar or lower than the other equations, with the largest difference seen for Crapo equations (median: −1.25, IQR: −1.64, 0.86 mmol·min−1·kPa−1). These differences resulted in altered rates of reduced TLCO for GLI particularly for adults (+1.9% versus Miller to −27.6% versus Crapo), more so than for children (−0.8% versus Kim to −14.2% versus Cotes). For adults, the highest raw agreement for GLI was with Miller equations (94.7%), while for children it was with Kim equations (98.1%). Results were reclassified from abnormal to normal more frequently for younger adults, and for adult females, particularly when moving from Roca to GLI equations (30% of females versus 16% of males).The adoption of GLI TLCO reference equations in adults will result in altered interpretation depending on the equations previously used and to a greater extent in adult females. The effect on interpretation in children is less significant.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Mr. Brazzale has nothing to disclose.Conflict of interest: Dr. Seccombe has nothing to disclose.Conflict of interest: Dr. Welsh has nothing to disclose.Conflict of interest: Dr. Lanteri has nothing to disclose.Conflict of interest: Dr. Farah has nothing to disclose.Conflict of interest: Dr. Ruehland has nothing to disclose. ER -