TY -的T1 Upregulation平滑肌Rho-kinase protein expression in human asthma JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01785-2019 VL - 55 IS - 3 SP - 1901785 AU - Wang, Lu AU - Chitano, Pasquale AU - Paré, Peter D. AU - Seow, Chun Y. Y1 - 2020/03/01 UR - //www.qdcxjkg.com/content/55/3/1901785.abstract N2 - The lack of bronchodilatory response to deep inspiration in asthmatics is thought to be partially due to reduced airway distensibility [1, 2], possibly caused by an increase in airway smooth muscle (ASM) tone and stiffness [3]. Rho-kinase (ROCK) is known to play a role in regulating ASM tone [4] and ASM cytoskeletal stiffness [5].An important phenotypic change is associated with human asthma: the protein expression of both isoforms of Rho-kinase, ROCK1 and ROCK2, is increased in the smooth muscles of intra-parenchymal airways and in the pulmonary blood vessels http://bit.ly/2pPfyxH ER -