PT - 日刊文AU - Waschki，本杰明AU - 阿尔特，彼得AU - 泽勒，塔尼娅AU - 马格努森，克里斯蒂娜AU - 诺伊曼，约翰T. AU - Twerenbold，拉斐尔AU - 犯罪，克里斯托夫AU - 杜林，基督教AU - Kahnert，席AU - Fähndrich，塞巴斯蒂安AU - Blankenberg，斯特凡AU - 拉贝，克劳斯F. AU - 威尔特，托比亚斯AU - Jörres，鲁道夫A. AU - Vogelmeier，克劳斯F. AU - 的Bals，罗伯特AU - Watz，亨里克·ED - ，TI - 肌钙蛋白I高灵敏度和患者的全因死亡率与稳定的慢性阻塞性肺病：在COSYCONET研究AID的分析 - 10.1183 / 13993003.01314-2019 DP - 2020年2月1 TA - 欧洲呼吸杂志PG - 1901314 VI - 55 IP - 24099 - 4100 //www.qdcxjkg.com/content/55/2/1901314.short - //www.qdcxjkg.com/content/55/2/1901314.full SO - 欧洲呼吸J2020年2月1;55 AB - 慢性阻塞性肺疾病（COPD）是死亡与人口由心血管疾病死亡的相当一部分的首要原因。高敏肌钙蛋白I（HS-TNI）可能有助于更好地识别COPD患者死亡的高风险。我们的目的是研究HS-肌钙蛋白为超越既定的COPD评估全因死亡率的预测值，并考虑相关的心血管危险因素和流行的心血管疾病，在稳定COPD.Circulating HS-肌钙蛋白浓度广泛人群的用后一起广泛的呼吸系统和心血管标志物在2085名稳定期COPD患者进行了评价在所有的严重性阶段的多中心COSYCONET队列研究入选。The primary outcome was all-cause mortality over 3 years of follow-up.Hs-TnI was detectable in 2020 (96.9%) patients. The median hs-TnI concentration was 3.8 ng·L−1 (interquartile range 2.5–6.6 ng·L−1), with levels above the 99th percentile reference limit of 27 ng·L−1 observed in 1.8% of patients. In Cox regression analyses including adjustments for airflow limitation, dyspnoea grade, exercise capacity and history of severe exacerbations, as well as traditional cardiovascular risk factors, estimated glomerular filtration rate, ankle–brachial index, N-terminal pro-brain natriuretic peptides and prevalent cardiovascular diseases, hs-TnI was a significant predictor for all-cause mortality, both as a continuous variable (hazard ratio (HR) for log hs-TnI 1.28, 95% CI 1.01–1.62) and categorised according to the cut-off of 6 ng·L−1 (HR 1.63, 95% CI 1.10–2.42).In patients with stable COPD, hs-TnI is a strong predictor of all-cause mortality beyond established COPD mortality predictors, and independent of a broad range of cardiovascular risk factors and prevalent cardiovascular diseases. Hs-TnI concentrations well below the upper reference limit provide further prognostic value for all patients with COPD when added to established risk assessments.High-sensitivity troponin I is a strong predictor of all-cause mortality in patients with stable COPD independent from established mortality predictors of COPD and irrespective of their cardiovascular risk profile http://bit.ly/352ZtDw