％0期刊论文％A Bomanji，署Jamshed％A夏尔马Rajnish％A塔尔，Bhagwant R.％A甘比尔，桑杰％A Qureshy艾哈迈德％A卡莉达，沙米姆M.F.％A派斯，戴安娜％A Sathekge，麦克％A福斯特，马里萨％A Sobic萨拉诺维奇，德拉加娜％A Pusuwan，Pawana％A曼，维拉％A Vinjamuri，苏班％A Zumla，Alimuddin％A帕斯夸尔，托马斯注：在第一临床表现外结核病的％T PET / CT特性：具有横截面观察¹⁸跨越六个国家％d 2020％R 10.1183 / 13993003.01959-2019％Ĵ欧洲呼吸杂志％P 1901959％V 55％N 2％X背景技术F-FDG成像研究的肺外结核（EPTB）情况下的巨大全球负担大的比例凭经验处理而不疾病部位的准确定义和多器官疾病的参与程度。正电子发射断层成像使用结核2-脱氧-2-（氟-18）氟d葡萄糖（18 F-FDG）可以是用于本地化disease.Methods的疾病部位和程度我们进行了一种有用的成像技术（PET）HIV阴性的成年患者跨设在六个国家八个中心新的临床诊断EPTB的研究：印度，巴基斯坦，泰国，南非，塞尔维亚和孟加拉国，评估疾病和涉及首先介绍常见的部位的程度。18F-FDG PET/computed tomography (CT) scans were performed within 2 weeks of presentation.Findings 358 patients with EPTB (189 females; 169 males) were recruited over 45 months, with an age range of 18–83 years (females median 30 years; males median 38 years). 350 (98%) out of 358 patients (183 female, 167 male) had positive scans. 118 (33.7%) out of 350 had a single extrapulmonary site and 232 (66.3%) out of 350 had more than one site (organ) affected. Lymph nodes, skeleton, pleura and brain were common sites. 100 (28%) out of 358 EPTB patients had 18F-FDG PET/CT-positive sites in the lung. 110 patients were 18F-FDG PET/CT-positive in more body sites than were noted clinically at first presentation and 160 patients had the same number of positive body sites.Interpretation 18F-FDG PET/CT scan has potential for further elucidating the spectrum of disease, pathogenesis of EPTB and monitoring the effects of treatment on active lesions over time, and requires longitudinal cohort studies, twinned with biopsy and molecular studies.18F-FDG PET/CT can localise EPTB disease sites not clinically detected. It may serve a useful tool for research studies defining pathogenetic mechanisms and cure, relapse and recurrence. http://bit.ly/2CKSH9a %U //www.qdcxjkg.com/content/erj/55/2/1901959.full.pdf