TY -的T1 -呼出挥发性有机化合物作为药物使用的标记在哮喘JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00544 -2019欧元六世- 55 - 2 SP - 1900544 AU边缘主义者保罗AU -艾哈迈德,Waqar m . AU -戈麦斯,克里斯蒂娜盟——Knobel雨果h . AU - Weda汉斯盟——Vink Teunis J . AU - Nijsen,塔玛拉·m . AU -惠洛克,克雷格•e . AU - Dahlen Sven-Erik盟——Montuschi保罗AU -诺尔斯,理查德·g . AU - Vijverberg Susanne J . AU - Maitland-van der ZeeAnke h . AU -斯德克已,Peter j . AU -福勒,Stephen j . Y1 - 2020/02/01 UR - //www.qdcxjkg.com/content/55/2/1900544.abstract N2 -介绍异构条件,哮喘是一种慢性炎症为特征的航空公司,通常通过吸入支气管扩张剂和糖皮质激素。对于无法控制的哮喘，通常需要口服糖皮质激素(OCSs)。良好的坚持和吸入技术与改善预后相关;然而，很难监测适当的药物摄入和有效性的个别病人。呼出的口气含有成千上万的挥发性有机化合物(VOCs)，它们反映了人体化学成分的变化，可能对监测药物的药代动力学/药效学有帮助。我们的目的是通过U-BIOPRED队列(气相色谱-飞行时间质谱联用)研究重症哮喘患者呼出的VOCs与尿液中沙丁胺醇和OCSs水平的相关性(液相色谱-高分辨率质谱联用)。方法在基线和随访12-18个月后收集样本。统计分析基于单变量和多变量建模，然后计算接收机工作特性曲线下面积(AUC)。结果通过纵向复制和独立验证得到验证。结果78例患者(基线48例，复制30例，验证30例)均有有效数据。 Baseline AUC values were 82.1% (95% CI 70.4–93.9%) for salbutamol and 78.8% (95% CI 65.8–91.8%) for OCS. These outcomes could be adequately replicated and validated. Additional regression analysis between qualified exhaled VOCs and urinary concentrations of salbutamol and prednisone showed statistically significant correlations (p<0.01).Conclusion We have linked exhaled VOCs to urinary detection of salbutamol and OCSs. This merits further development of breathomics into a point-of-care tool for therapeutic drug monitoring.Exhaled volatile organic compounds can be linked to urinary traces of salbutamol and oral corticosteroids. This suggests that breathomics qualifies for development into a point-of-care tool for monitoring asthma drug level changes. http://bit.ly/2Hu4TOf ER -