TY - JOUR T1 - 不处理被引导分数呼出气一氧化氮在哮喘患儿的分组改善预后？JF - 欧洲呼吸杂志JO - EUR呼吸杂志DO - 10.1183 / 13993003.01879-2019 SP - 1901879 AU - 菲尔丁，绍纳S. AU - Pijnenburg，Marielle AU - 德Jongste，约翰AU - 派克，凯瑟琳AU - 罗伯茨，格雷厄姆AU -Petsky，海伦AU - 张，安妮B. AU - 弗里奇，玛丽亚AU - Frischer，托马斯AU - Szefler，斯坦利J. AU - 格根，彼得AU - Vermeulen的，弗朗索瓦丝AU - Vael，罗宾AU - 特纳，史蒂夫S. Y1- 2020年1月1日UR - //www.qdcxjkg.com/content/early/2020/02/20/13993003.01879-2019.abstract N2 - 介绍分数呼出的一氧化氮（FENO），嗜酸细胞性气道炎症的生物标志物，可以是导哮喘治疗是有用的。FENO引导治疗可能在某些亚组用于改进相对于标准治疗。方法使用来自七个数据随机其用于FENO引导哮喘治疗的临床试验（RCT）进行单独的患者的数据分析结果的哮喘更有效。的哮喘恶化和控制的损失，且时间第一恶化和失控的发生率RCT participants.Results数据的五个分组之间描述均1112名RCT参与者可用。在那些不与白三烯受体拮抗剂（LTRA），但不能在那些谁用LTRA治疗处理，FENO引导治疗与降低的恶化风险（比值比（OR）0.68 [95％CI 0.49，0.94]），较长的时间相关联到第一恶化（危险比（HR）0.76 [0.57，0.99]）和临界风险降低用于控制的损失（OR 0.70 [0.49，1.00]）。非肥胖儿童相比，肥胖儿童，不太可能失去控制哮喘治疗时被FENO指导（0.69 [0.48，0.99] OR）和时间失控较长（HR 0.77 [0.61，0.99]）。结论哮喘治疗的FENO引导可能是在谁不与LTRA治疗，谁不肥胖者相比，手稿最近已经接受了在欧洲呼吸杂志出版标准practice.FootnotesThis患者达到更好的哮喘效果更加有效。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Fielding has nothing to disclose.Conflict of interest: Dr. Pijnenburg has nothing to disclose.Conflict of interest: Dr. de Jongste has nothing to disclose.Conflict of interest: Dr. Pike has nothing to disclose.Conflict of interest: Dr. Roberts has nothing to disclose.Conflict of interest: Dr. Petsky has nothing to disclose.Conflict of interest: Dr. Chang reports grants (project, Centre for Research Excellence and practitioner fellowship) from the National Health and Medical Research Council, Australia during the conduct of the study; and other potential conflict from being an author in UpToDate and USA Chest Chronic Cough Guidelines outside the submitted work.Conflict of interest: Dr. Fritsch has nothing to disclose.Conflict of interest: Dr. Fritscher has nothing to disclose.Conflict of interest: Dr. Szefler has nothing to disclose.Conflict of interest: Dr. Gergen has nothing to disclose.Conflict of interest: Dr. Vermeulen has nothing to disclose.Conflict of interest: Dr. Vael has nothing to disclose.Conflict of interest: Dr. Turner has nothing to disclose. ER -