TY - JOUR T1 - 气道G-CSF识别中性粒细胞炎症及有助于哮喘恶化JF - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.00827-2019 VL - 55 - 2 SP - 1900827 AU - 金，杨敏AU - 金，Hyekang AU - 李，Seungwon AU - 金，索拉非盟 - 李，钟屋AU - 财，Youngwoo AU - 公园，汉旭AU - 你，Gihoon AU - 康，韩松AU - 李，Seyoung AU -公园，钟淑AU - 公园，云髻AU - 公园，海，辛AU - 公园，椿植AU - 李升宇Y1 - 2020年2月1日UR - //www.qdcxjkg.com/内容/ 55/2 / 1900827.abstract N2 - 根据相关的生物标志物的哮喘患者的分层使得针对哮喘患者的免疫靶向疗法响应的预测。患者嗜酸性哮喘的个体化治疗，取得了改善临床结果;患者的嗜中性粒细胞性哮喘类似的方法还有待开发。我们确定在气道细胞集落刺激因子（CSF）是否反映哮喘的炎性表型和根据与哮喘分层有助于嗜中性asthma.We的疾病进展进行分析哮喘的三个不同的小鼠模型，并评估细胞因子谱在痰从人类患者炎症表型。此外，我们通过促进嗜中性粒细胞发展骨髓评价各种细胞因子封锁的治疗功效在嗜中性粒细胞asthma.Among所述CSF，气道粒细胞CSF（G-CSF）有助于气道中性粒细胞增多的小鼠模型中，从而区分嗜酸性粒细胞中性粒细胞炎症炎症在哮喘的小鼠模型。 G-CSF is produced by concurrent stimulation of the lung epithelium with interleukin (IL)-17A and tumour necrosis factor (TNF)-α; therefore, dual blockade of upstream stimuli using monoclonal antibodies or genetic deficiency of the cytokines in IL-17A×TNF-α double-knockout mice reduced the serum level of G-CSF, leading to alleviation of neutrophilic inflammation in the airway. In humans, the sputum level of G-CSF can be used to stratify patients with asthma with neutrophil-dominated inflammation.Our results indicated that myelopoiesis-promoting G-CSF and cytokines as the upstream inducing factors are potential diagnostic and therapeutic targets in patients with neutrophilic asthma.Airway G-CSF identifies neutrophil-dominated inflammation in cases of asthma in mice and humans. Dual inhibition of IL-17A and TNF-α effectively ameliorates airway neutrophilia and hyperresponsiveness in a mouse model of neutrophilic asthma. http://bit.ly/36P04dB ER -