TY - JOUR T1 - 饮食抗氧化剂摄入量在学龄期及肺功能发展到青春期JF - 欧洲呼吸杂志JO - EUR呼吸杂志DO - 10.1183 / 13993003.00990-2019 VL - 55 - 2 SP - 1900990 AU - Sdona,Emmanouela AU- Hallberg的,珍妮AU - 安德森,尼克拉斯AU - 埃克斯特罗姆,桑德拉AU - 劳蒂埃宁,苏珊AU - 哈坎森,尼克拉斯AU - 沃尔克,阿莉恰AU - 库尔,英格AU - 梅伦,埃里克AU - 伯格斯特龙,安娜Y1 - 2020/02 /01 UR - //www.qdcxjkg.com/content/55/2/1900990.abstract N2 - 饮食抗氧化剂摄入量已经假说认为影响肺功能。The association between total antioxidant capacity (TAC) of the diet at age 8 years and lung function development up to 16 years in 2307 participants from the Swedish population-based birth cohort BAMSE (Children, Allergy, Milieu, Stockholm, Epidemiology) was investigated.Information on TAC was obtained from a food frequency questionnaire at 8 years. Lung function was measured by spirometry at 8 and 16 years, impulse oscillometry (IOS) and exhaled nitric oxide fraction (FeNO) at 16 years. Low lung function was defined as forced expiratory volume in 1 s (FEV1) z-score below the 25th percentile. Longitudinal associations between TAC and lung function were analysed by mixed effect models adjusted for potential confounders. Stratification by asthma at 8 years was performed to examine effect modification.The median TAC intake was 10 067 μmol Trolox equivalents (TE)·g−1, with males having a lower mean compared to females (9963 versus 10 819 μmol TE·g−1). In analyses of lung function change between 8 and 16 years, there were no statistically significant associations between TAC in tertiles and spirometry results for the total study population. Among children with asthma at 8 years (prevalence 7%), higher TAC was associated with higher mean FEV1 (0.46 sd, 95% CI 0.11–0.80) and decreased odds of low lung function at 16 years (OR 0.28, 95% CI 0.12–0.65). There were no associations between TAC and forced vital capacity or IOS/FeNO results.High dietary antioxidant intake in school age may be associated with improved lung function development from school age to adolescence among children with asthma.Dietary antioxidant intake at school age may influence lung function development as measured by FEV1 up to adolescence among children with asthma. In contrast, no association was observed among children without asthma. http://bit.ly/2CzEZ8W ER -