TY - - JOUR T1哮喘急性发作的妊娠妇女哮喘时生效：基于人群的队列研究JF - 欧洲呼吸杂志JO - EUR呼吸杂志DO - 10.1183 / 13993003.01335-2019 VL - 55 - 2 SP - 1901335 AU -阿卜杜拉Kawsari AU - 朱，精勤AU - 葛森，安德烈AU - 戴尔，沙龙AU - 要，邓丽君Y1 - 2020年2月1日UR - //www.qdcxjkg.com/content/55/2/1901335。抽象N2 - 怀孕和不良孕产妇和儿童健康结果在哮喘急性发作之间的关联没有得到适当的调查。我们的目标是，以确定孕妇asthma.A人群队列研究哮喘急性发作的短期和长期的代际效应使用从安大略哮喘监控系统和人口级卫生行政数据数据进行的。哮喘加重孕妇哮喘被定义为以下标准的至少一个：至少五个就诊，或一个急诊就诊或妊娠期哮喘一个住院。Pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders were identified using International Classification of Disease codes (9th and 10th revisions).The cohort consisted of 103 424 singleton pregnancies in women with asthma. Asthma exacerbation in pregnant women with asthma was associated with higher odds of pre-eclampsia (OR 1.30, 95% CI 1.12–1.51) and pregnancy-induced hypertension (OR 1.17, 95% CI 1.02–1.33); babies had higher odds of low birthweight (OR 1.14, 95% CI 1.00–1.31), preterm birth (OR 1.14, 95% CI 1.01–1.29) and congenital malformations (OR 1.21, 95% CI 1.05–1.39). Children born to women with asthma exacerbation during pregnancy had elevated risk of asthma (OR 1.23, 95% CI 1.13–1.33) and pneumonia (OR 1.12, 95% CI 1.03–1.22) during the first 5 years of life.Asthma exacerbation during pregnancy in women with asthma showed increased risk of pregnancy complications, adverse perinatal outcomes and early childhood respiratory disorders in their children, indicating that appropriate asthma management may reduce the risk of adverse health outcomes.This study shows that women with asthma having asthma exacerbation during pregnancy have increased risk of adverse maternal and child health outcomes. Women with asthma during pregnancy require appropriate asthma management and follow-up. http://bit.ly/2Nh8q61 ER -