TY - JOUR T1 - 孟德尔随机红细胞分布的分析宽度在肺动脉高血压JF - 欧洲呼吸杂志JO - 欧洲呼吸j执行 - 10.1183 / 13993003.01486-2019 VL - 55 - 2 SP - 1901486 AU - 乌尔里希，安娜AU -沃顿商学院，约翰AU - 塞耶，蒂莫西·E. AU - Swietlik，艾米利亚M. AU - 阿萨德，Tufik R. AU - 德赛，ANKIT A. AU - 格拉夫，斯特凡AU - Harbaum，拉尔斯AU - 亨伯特，马克AU - 莫雷尔尼古拉斯W. AU - 尼科尔斯，威廉C. AU - Soubrier，弗洛朗AU - 索斯盖特，劳拉AU - Trégouët，大卫 - 亚历山大AU - TREMBATH，理查德C. AU - 布里泰恩，埃文L. AU - 威尔金斯，马丁R. AU -普罗科普恩科，因加AU - 罗得岛，克里斯托弗J. A2 - ， - ，Y1 - 2020年2月1日UR - //www.qdcxjkg.com/content/55/2/1901486.abstract N2 - 肺动脉高压（PAH）是一种罕见的疾病，从右侧心脏衰竭导致过早死亡。强烈与升高的红细胞分布宽度（RDW），若干铁状态的生物标志物相关成分的一个相关联。高RDW值可以用信号早期缺铁或缺铁性贫血。本研究调查是否升高RDW有因果与PAH.A双样本孟德尔随机（MR）方法应用于研究遗传易感性更高水平的RDW是否增加显影PAH的可能性相关联。使用所有可用的全基因组显著RDW进行初级和次级分析MR变体（N = 179）和五个全基因组显著RDW通过全身铁状态的变体的行为，证实respectively.We RDW和PAH之间的观察到的关联（OR 1.90, 95% CI 1.80–2.01) in a multicentre case–control study (cases n=642, disease controls n=15 889). The primary MR analysis was adequately powered to detect a causal effect (odds ratio) between 1.25 and 1.52 or greater based on estimates reported in the RDW genome-wide association study or from our own data. There was no evidence for a causal association between RDW and PAH in either the primary (ORcausal 1.07, 95% CI 0.92–1.24) or the secondary (ORcausal 1.09, 95% CI 0.77–1.54) MR analysis.The results suggest that at least some of the observed association of RDW with PAH is secondary to disease progression. Results of iron therapeutic trials in PAH should be interpreted with caution, as any improvements observed may not be mechanistically linked to the development of PAH.Mendelian randomisation using genetic data from the largest-to-date PAH cohort does not support red cell distribution width or iron deficiency as a cause of PAH, which is important when interpreting iron replacement trials in this condition http://bit.ly/2PPaa88 ER -