TY - T1的偶然在癌症患者静脉血栓栓塞的临床意义JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01697 -2019欧元六世- 55 - 2 SP - 1901697 AU -莫特,熔化。非盟- Di Nisio,马塞洛非盟- Ay, Cihan AU -载体,马克•AU -博世Floris T.M. AU -塞格尔,Annelise盟——Kraaijpoel Noemie AU -格罗索,Michael a . AU -张,彼得•王盟——乔治•AU - Verhamme Tzu-Fei AU -韦茨,杰弗里。非盟- Middeldorp Saskia AU - Raskob,加里•AU - Beenen骰子游戏F.M. AU -布勒,哈利r . AU - van Es,尼克Y1 - 2020/02/01 UR - //www.qdcxjkg.com/content/55/2/1901697.abstract N2 -介绍癌症患者,目前指导建议类似治疗偶然和症状性静脉血栓栓塞(VTE),主要基于回顾数据。我们的目的是评估抗凝治疗在癌症患者偶然和症状性静脉血栓栓塞。方法北斋VTE癌症研究是一项随机对照试验，比较依多沙班和达尔特帕林治疗癌症相关VTE。主要结果为首次复发性静脉血栓栓塞或大出血。次要结果包括大出血、静脉血栓栓塞复发和死亡率。在12个月的研究期间，评估了偶然发生和有症状的静脉血栓栓塞患者的预后。结果331例偶发性静脉血栓栓塞患者和679例有症状性静脉血栓栓塞患者被纳入研究，其中指标事件经独立放射科医师确诊。抗凝治疗的中位时间分别为195天和189天。在偶发性静脉血栓栓塞患者中，12.7%的患者出现主要结果，6.6%的患者出现大出血，7.9%的患者出现复发性静脉血栓栓塞。 Out of the 26 VTE recurrences in patients with incidental VTE, five (31%) were incidental, seven (44%) were symptomatic and four (25%) were deaths for which pulmonary embolism could not be ruled out. In patients with symptomatic VTE, the primary outcome occurred in 13.8% of patients, major bleeding in 4.9% of patients and recurrent VTE in 10.9% of patients. All-cause mortality was similar in both groups.Conclusion Clinical adverse outcomes are substantial in both cancer patients with incidental and symptomatic VTE, supporting current guideline recommendations that suggest treating incidental VTE in the same manner as symptomatic VTE.In cancer patients with incidental venous thromboembolism (VTE), the risk of recurrent VTE is substantial despite initiation of anticoagulant treatment. Incidental VTE is a serious condition, which should be treated similar to symptomatic VTE. http://bit.ly/2qM4XUp ER -