TY - T1的揭露exerti的机制onal dyspnoea in combined pulmonary fibrosis and emphysema JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01319-2019 VL - 55 IS - 1 SP - 1901319 AU - Costa, Camila M. AU - Neder, J. Alberto AU - Verrastro, Carlos G. AU - Paula-Ribeiro, Marcelle AU - Ramos, Roberta AU - Ferreira, Eloara M. AU - Nery, Luiz E. AU - O'Donnell, Denis E. AU - Pereira, Carlos A.C. AU - Ota-Arakaki, Jaquelina Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/55/1/1901319.abstract N2 - The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxaemia. However, there is little evidence to support these assumptions.We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients matched by the severity of exertional hypoxaemia. Emphysema and pulmonary fibrosis were quantified using computed tomography. Inspiratory constraints were assessed in a constant work rate test: capillary blood gases were obtained in a subset of patients.CPFE patients had lower exercise capacity despite less extensive fibrosis compared to IPF (p=0.004 and 0.02, respectively). Exertional dyspnoea was the key limiting symptom in 24 CPFE patients who showed significantly lower transfer factor, arterial carbon dioxide tension and ventilatory efficiency (higher minute ventilation (V′E)/carbon dioxide output (V′CO2) ratio) compared to those with less dyspnoea. However, there were no between-group differences in the likelihood of pulmonary hypertension by echocardiography (p=0.44). High dead space/tidal volume ratio, low capillary carbon dioxide tension emphysema severity (including admixed emphysema) and traction bronchiectasis were related to a high V′E/V′CO2 ratio in the more dyspnoeic group. V′E/V′CO2 nadir >50 (OR 9.43, 95% CI 5.28–13.6; p=0.0001) and total emphysema extent >15% (2.25, 1.28–3.54; p=0.01) predicted a high dyspnoea burden associated with severely reduced exercise capacity in CPFEContrary to current understanding, hypoxaemia per se is not the main determinant of exertional dyspnoea in CPFE. Poor ventilatory efficiency due to increased “wasted” ventilation in emphysematous areas and hyperventilation holds a key mechanistic role that deserves therapeutic attention.Exertional dyspnoea is related to poor ventilatory efficiency rather than hypoxaemia or inspiratory constraints in CPFE. Lessening patients' excessive ventilation might prove particularly beneficial to mitigate the burden of this disabling symptom. http://bit.ly/2MRn6az ER -