PT -期刊文章AU -辛普森,凯瑟琳e . AU -陈,珍妮y . AU - Damico,雷切尔·l . AU -哈桑,Paul m . AU -马丁,丽莎·j . AU -杨,君非盟- Nies,梅勒妮AU -格里菲斯,梅根盟——Vaidya r . Dhananjay AU - Brandal,斯蒂芬妮AU - Pauciulo,迈克尔·w . AU -鲁兹,凯蒂·a . AU -科尔曼,安娜·w . AU -奥斯汀,埃里克·d . AU -常春藤,邓巴d . AU -尼科尔斯,威廉·c·AU -埃弗雷特,艾伦·d·TI -细胞来源的il - 6与临床表型和结果的PAH援助协会- 10.1183/13993003.01761 -2019 DP - 2020年1月01 TA -欧洲呼吸杂志PG - 1901761 4099 - //www.qdcxjkg.com/content/early/2020/01/16/13993003.01761 - 2019. -短4100 - //www.qdcxjkg.com/content/early/2020/01/16/13993003.01761 - 2019. -完整的AB -促炎症细胞因子白细胞介素- 6 (il - 6)与结果在小肺动脉高血压有关(PAH)队列主要由重症特发性PAH (IPAH)患者组成。目前尚不清楚IL-6是危重症的标志物还是肺血管重构的机械性生物标志物。我们假设IL-6是由肺血管细胞产生的，并试图在一个多环芳烃多环芳烃大队列中探索IL-6与不同亚型表型和预后的关系。检测肺动脉平滑肌细胞(PASMCs)和内皮细胞(PAECs)中IL-6蛋白和基因的表达水平。在2017年测定了代表多环芳烃亚群特征良好的多环芳烃受试者的血清IL-6。用回归模型分析IL-6水平、临床变量和死亡率之间的关系。在PAH中，PASMCs产生的IL-6蛋白和基因表达水平明显高于PAECs (p<0.001)，而在对照组中，IL-6在细胞类型之间没有差异。与门脉高压和结缔组织疾病(CTD-PAH)相关的多环芳烃中，血清IL-6水平最高。 In multivariable modelling, serum IL-6 was associated with survival in the overall cohort (HR 1.22, 95% CI 1.08–1.38, p<0.01) and in IPAH, though not in CTD-PAH. IL-6 remained associated with survival in low-risk subgroups of subjects with mild disease.IL-6 is released from PASMCs, and circulating IL-6 is associated with specific clinical phenotypes and outcomes in various PAH subgroups, including subjects with less severe disease. IL-6 is a mechanistic biomarker, and thus a potential therapeutic target, in certain PAH subgroups.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Simpson has nothing to disclose.Conflict of interest: Dr. Chen has nothing to disclose.Conflict of interest: Dr. Damico has nothing to disclose.Conflict of interest: Dr. Hassoun has nothing to disclose.Conflict of interest: Dr. Martin has nothing to disclose.Conflict of interest: Dr. Yang has nothing to disclose.Conflict of interest: Dr. Nies has nothing to disclose.Conflict of interest: Dr. Griffiths has nothing to disclose.Conflict of interest: Dr. Vaidya has nothing to disclose.Conflict of interest: Dr. Brandal has nothing to disclose.Conflict of interest: Dr. Pauciulo has nothing to disclose.Conflict of interest: Katie A. Lutz has nothing to disclose.Conflict of interest: Anna W. Coleman has nothing to disclose.Conflict of interest: Dr. Austin has nothing to disclose.Conflict of interest: Dr. Ivy has nothing to disclose.Conflict of interest: Dr. Nichols has nothing to disclose.Conflict of interest: Dr. Everett has nothing to disclose.