RT期刊论文SR电子T1急性哮特异性基因模块示出了与维生素d和哮喘的药物相关性JF欧洲呼吸杂志JO欧洲呼吸ĴFD欧洲呼吸协会SP 1901330 DO 10.1183 / 13993003.01330-2019 VO 55是1 A1片山，太郎A1 Stenberg发明188bet官网地址Hammar的，卡塔琳娜托A1Krjutškov，Kaarel A1 Einarsdottir，伊丽莎白A1 Hedlin，古尼拉A1克惹，尤哈A1Söderhäll，西拉YR 2020 UL //www.qdcxjkg.com/content/55/1/1901330.abstract AB背景气道阻塞和在学龄前小儿反复病毒感染喘息是一个主要的临床问题，并确认为慢性哮喘的危险因素。We aimed to analyse whether gene expression profiling provides evidence for pathways that delineate distinct groups of children with wheeze, and in combination with clinical information could contribute to diagnosis and prognosis of disease development.Methods We analysed leukocyte transcriptomes from preschool children (6 months–3 years) at acute wheeze (n=107), and at a revisit 2–3 months later, comparing them to age-matched healthy controls (n=66). RNA-sequencing applying GlobinLock was used. The cases were followed clinically until age 7 years. Differential expression tests, weighted correlation network analysis and logistic regression were applied and correlations to 76 clinical traits evaluated.Findings Significant enrichment of genes involved in the innate immune responses was observed in children with wheeze. We identified a unique acute wheeze-specific gene-module, which was associated with vitamin D levels (p<0.005) in infancy, and asthma medication and FEV1%/FVC (forced expiratory volume in 1 s/forced vital capacity) ratio several years later, at age 7 years (p<0.005). A model that predicts leukotriene receptor antagonist medication at 7 years of age with high accuracy was developed (area under the curve 0.815, 95% CI 0.668–0.962).Interpretation Gene expression profiles in blood from preschool wheezers predict asthma symptoms at school age, and therefore serve as biomarkers. The acute wheeze-specific gene module suggests that molecular phenotyping in combination with clinical information already at an early episode of wheeze may help to distinguish children who will outgrow their wheeze from those who will develop chronic asthma.Gene expression profiles at acute preschool wheeze correlate with vitamin D, and asthma medication and lung function several years later. These profiles provide candidate prognostic biomarkers and support the role of immune response in preschool wheeze. http://bit.ly/318Ilde