TY-Jour T1 - 初级睫状体缺血剂患者具有相同的 p。铜绿假单胞菌和肺部和肺部克隆JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.01472-2019 VL - 55是 - 1 SP - 1901472 Au - Arndal，Elisabeth Au - Johansen，Helle K. Au -Haagensen, Janus A.J. AU - Bartell, Jennifer A. AU - Marvig, Rasmus L. AU - Alanin, Mikkel AU - Aanæs, Kasper AU - Høiby, Niels AU - Nielsen, Kim G. AU - Backer, Vibeke AU - von Buchwald, Christian Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/55/1/1901472.abstract N2 - Similar to patients with cystic fibrosis (CF) and non-CF bronchiectasis, patients with primary ciliary dyskinesia (PCD) are prone to recurrent or chronic lung infections with Pseudomonas aeruginosa. Chronic P. aeruginosa lung infection has a prevalence of up to 39% in patients with PCD [1] and is associated with structural damage, affecting lung function. Treatment of P. aeruginosa infection is challenging because P. aeruginosa adapts to the host environment through genotypic/phenotypic changes, promoting a reduced immune response [2].For the first time it is shown that the same Pseudomonas aeruginosa clone exists in both the upper and lower airways in patients with PCD, providing a solid support of the unified airway theory where the sinuses are a possible bacterial reservoir http://bit.ly/2kcE9tq ER -