TY - T1的外周血白细胞端粒长度与脓毒症患者的存活期JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01044 -2019欧元六世- 55 - 1 SP - 1901044 AU刘烁AU - Wang Chunxue盟——绿色,加里盟——卓,汉京盟——刘,凯瑟琳·d . AU - Kangelaris,克里斯汀•n . AU -戈麦斯,安东尼奥AU -哈乌雷吉曾Alejandra AU -船,凯瑟琳AU -柯,小威盟-亨德里克森,卡洛琳AU - Matthay, Michael a . AU - CalfeeN2 -外周血白细胞(PBL)端粒长度(TL)较短与各种慢性肺部疾病预后差有关。本研究检验了PBL-TL是否与危重疾病生存率相关。我们分析了来自范德比尔特大学医学中心(VUMC) 937名危重患者的前瞻性观察队列研究的数据。用定量PCR方法对PBL-TL进行检测。研究结果在一个独立队列中得到了验证，该队列由394名被加州大学旧金山分校(UCSF)收治的危重症脓毒症患者组成。在VUMC队列中，较短的PBL-TL与较差的90天生存率相关(校正危险比(aHR) 1.3, 95% CI 1.1-1.6 / 1 kb TL下降;p = 0.004);在亚组分析中，较短的PBL-TL与脓毒症患者90天生存期恶化相关(aHR 1.5, 95% CI 1.2-2.0 / 1 kb TL下降;p=0.001)，但无外伤。虽然与急性呼吸窘迫综合征(ARDS)的发生无关，但在ARDS受试者中，较短的PBL-TL与更严重的ARDS相关(OR 1.7, 95% CI 1.2-2.5 / 1 kb TL下降; p=0.006). The associations of PBL-TL with survival (adjusted HR 1.6, 95% CI 1.2–2.1 per 1 kb TL decrease; p=0.003) and risk for developing severe ARDS (OR 2.5, 95% CI 1.1–6.3 per 1 kb TL decrease; p=0.044) were validated in the UCSF cohort.Short PBL-TL is strongly associated with worse survival and more severe ARDS in critically ill patients, especially patients with sepsis. These findings suggest that telomere dysfunction may contribute to outcomes from critical illness.Shorter peripheral blood leukocyte telomere length is strongly associated with worse survival and more severe ARDS in critically ill patients with sepsis http://bit.ly/2mWHKxf ER -