％0期刊文章％A刘，呼吸％王，春兴％绿色，加里％a zhuo，汉语％a liu，kathleen d.％a kangelaris，kirsten n.％a gomez，Antonio％a Jauregui，Alejandra％a船只，Kathryn％A Ke，Serena％Hendrickson，Carolyn％A Matthay，Michael A.％A Calfee，Carolyn S.％A Wilter，Lorraine B.％A泡沫，Paul J.％T外周血白细胞端粒细胞端粒细胞端粒体端粒长度随着SEPSIS患者的存活率％D 2020％R 10.1183 / 13993003.01044-2019％J欧洲呼吸期轴颈％P 1901044％V 55％N 1％X短外围血白细胞（PBL）端粒长度（TL）已经与差的结果相关各种慢性肺病。在本研究中测试了PBL-TL是否与危重疾病的存活相关。我们分析了Vanderbilt大学医疗中心（VUMC）937危重患者的前瞻性观察队课程的数据。使用从PBLS分离的DNA的定量PCR测量PBL-T1。在394次综合症患者中验证了调查结果，患有加州大学旧金山（UCSF）。在VUMC队列中，较短的PBL-TL与较差的90天存活（调整危险比（AHR）有关1.3,95％CI 1.1-1.6每1 KB TL降低; P = 0.004）;在亚组分析中，较短的PBL-T1与败血症患者的较差的90天存活有关（AHR 1.5,95％CI 1.2.0每1kB T1降低; P = 0.001），但不是创伤。尽管与急性呼吸窘迫综合征（ARDS）的发展无关，但在ARDS受试者中，较短的PBL-T1与更严重的ARDS（或1.7,95％CI 1.2.2.5每1kb T1降低相关; P = 0.006）。 The associations of PBL-TL with survival (adjusted HR 1.6, 95% CI 1.2–2.1 per 1 kb TL decrease; p=0.003) and risk for developing severe ARDS (OR 2.5, 95% CI 1.1–6.3 per 1 kb TL decrease; p=0.044) were validated in the UCSF cohort.Short PBL-TL is strongly associated with worse survival and more severe ARDS in critically ill patients, especially patients with sepsis. These findings suggest that telomere dysfunction may contribute to outcomes from critical illness.Shorter peripheral blood leukocyte telomere length is strongly associated with worse survival and more severe ARDS in critically ill patients with sepsis http://bit.ly/2mWHKxf %U //www.qdcxjkg.com/content/erj/55/1/1901044.full.pdf