@Article {liu1901044，作者= {刘，硕和王，春兴和绿色，加里和卓，汉语和刘，卡特琳d。和kangelaris，kirsten n和戈麦斯，安东尼奥和jauregui，alejandra和船只，kathryn和ke，Serena和Hendrickson，Carolyn和Matthay，Michael A.和Calfee，Carolyn S.和Ware，Lorraine B.和Wolters，Paul J.}，标题= {外周血白细胞端粒端粒长度与Sepsis患者的存活有关，体积={55}，Number = {1}，Elocation-Id = {1901044}，年= {2020}，DOI = {10.1183 / 13993003.01044-13993003.01044-2019}，出版商= 188bet官网地址{欧洲呼吸社会}，摘要= {较短的外周血白细胞（PBL）端粒长度（TL）与各种慢性肺病中的结果不佳。在本研究中测试了PBL-TL是否与危重疾病的存活相关。我们分析了Vanderbilt大学医疗中心（VUMC）937危重患者的前瞻性观察队课程的数据。使用从PBLS分离的DNA的定量PCR测量PBL-T1。在394次综合症患者中验证了调查结果，患有加州大学旧金山（UCSF）。在VUMC队列中，较短的PBL-TL与较差的90天存活（调整危险比（AHR）有关1.3,95 \％CI 1.1 {\ TextEndash} 1.6每1 KB TL减少; P = 0.004）;在亚组分析中，较短的PBL-TL与败血症患者的患者（AHR 1.5,95 \％CI 1.2 {\ TextEndash} 2.0每1kb T1减少）相关的较差的90天存活; P = 0.001），但不是创伤。虽然与急性呼吸窘迫综合征（ARDS）的发展无关，但在ARDS受试者中，较短的PBL-T1与更严重的ARDS（或1.7,95 \％CI 1.2 {\ TextEndash} 2.5相关联的PBL-T1相关; P =0.006）。PBL-T1与存活的关联（调节的HR 1.6,95 \％CI 1.2 {\ Textendash} 2.1每1kb T1减少; p = 0.003）和发育严重ARDS的风险（或2.5,95 \％CI 1.1 {\textendash}6.3 per 1 kb TL decrease; p=0.044) were validated in the UCSF cohort.Short PBL-TL is strongly associated with worse survival and more severe ARDS in critically ill patients, especially patients with sepsis. These findings suggest that telomere dysfunction may contribute to outcomes from critical illness.Shorter peripheral blood leukocyte telomere length is strongly associated with worse survival and more severe ARDS in critically ill patients with sepsis http://bit.ly/2mWHKxf}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/1/1901044}, eprint = {//www.qdcxjkg.com/content/55/1/1901044.full.pdf}, journal = {European Respiratory Journal} }