TY - T1的哮喘遗传易感性增加了室内空气污染的脆弱性JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01831 -2019欧元SP - 1901831 AU - Anke hul盟Aneesa万科AU -黛安娜灰色盟纳斯塔柯恩AU -茱莉亚•l . MacIsaac盟大卫T.S.林盟——凯蒂大肠Ramadori盟——彼得·d·狡猾的非盟-丹·斯坦盟Michael s . Kobor AU -希瑟·J·Zar Y1 - 2020/01/01 UR - //www.qdcxjkg.com/content/early/2020/01/03/13993003.01831 - 2019. -抽象N2 -介绍室内空气污染和母亲在怀孕期间吸烟与呼吸系统症状的婴儿,但很少知道直接与肺功能或与遗传风险因子的相互作用。我们检查协会室内颗粒物的直径≤10µm (PM10)曝光和母亲吸烟与婴儿肺功能和基因-环境交互作用的角色。方法Drakenstein儿童健康研究的数据,一个南非出生队列进行分析(N = 270)。肺功能测定在6周和1年的年龄和下呼吸道疾病(下呼吸道感染)事件记录。我们测量产前及产后PM10曝光使用设备放置在家庭和使用孕产妇产前接触烟草烟雾尿液可替宁的水平。遗传风险评分(GRS)决定协会与儿童哮喘(COA)在英国生物库是用来调查效果修改。结果前和产后暴露在可吸入颗粒物以及母亲在怀孕期间吸烟与肺功能降低有关在6周和1年以及下呼吸道感染的第一年。由于大量GRS之间的交互和产前接触PM10,婴儿携带COA-risk等位基因更容易PM10-associated减少肺功能(p-interaction = 0.007)。这种交互是在婴儿与非洲黑人血统(p-interaction = 0.001)和儿童不存在混合血统(p-interaction = 0.876)。结论PM10和母亲吸烟暴露与肺功能下降,婴儿具有更高敏感性的哮喘不利的遗传倾向,也依赖于婴儿的祖先。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。 After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Huels has nothing to disclose.Conflict of interest: Dr. Vanker reports grants from Bill & Melinda Gates Foundation (OPP1017641, grants from Discovery Foundation, grants from South African Thoracic Society AstraZeneca Respiratory Fellowship, grants from National Research Fund, South Africa, grants from CIDRI Clinical Fellowship, grants from Medical Research Council, South Africa, during the conduct of the study.Conflict of interest: Dr. Gray has nothing to disclose.Conflict of interest: Dr. Koen has nothing to disclose.Conflict of interest: Dr. MacIsaac has nothing to disclose.Conflict of interest: Dr. Lin has nothing to disclose.Conflict of interest: Dr. Ramadori has nothing to disclose.Conflict of interest: Dr. Sly has nothing to disclose.Conflict of interest: Dr. Stein reports personal fees from Lundbeck, personal fees from Biocodex, personal fees from Sun, outside the submitted work.Conflict of interest: Dr. Kobor has nothing to disclose.Conflict of interest: Dr. Zar reports grants from Bill and Melinda Gates Foundation, grants from NIH, grants from Wellcome Trust, grants from SA MRC, grants from National Research Foundation SA, grants from South African Thoracic Society, during the conduct of the study. ER -