PT - 日刊文AU - Bachert，克劳斯AU - 亨伯特，马克AU - Hanania，尼古拉A. AU - 张南盟 - 霍尔盖特，欧锦棠 - 布尔，罗兰AU - 经纪人，芭芭拉M. TI - 金黄色葡萄球菌的和IgE的诱导哮喘肠毒素：当前知识援助 - 10.1183 / 13993003.01592-2019 DP - 2020年1月1 TA - 欧洲呼吸杂志PG - 1901592 4099 - //www.qdcxjkg.com/content/early/2020/01/03/13993003.01592-2019.short 4100 - //www.qdcxjkg.com/content/early/2020/01/03/13993003.01592-2019.full AB - 虽然免疫球蛋白E是著名的生物标志物为早期-onset，其水平也会升高非过敏迟发性哮喘。然而，IgE的表达在后者的图案大多是多克隆的，与特异性IgE低或低于检测水平尽管增加的总IgE。迟发性重度哮喘患者中，特异性IgE对葡萄球菌肠毒素（SE-IgE）的可经常在血清中检测到，并且已经与哮喘相关，与肺功能由住院定义重度哮喘，口服类固醇的使用和降低。近日，SE-IgE的证明，甚至预测发展成为重症哮喘与未来十年加重。金黄色葡萄球菌在操纵通过它的蛋白质的各种级别，包括超抗原，丝氨酸蛋白酶样蛋白（声压级），或蛋白A（SPA）和可能的其他气道粘膜免疫。从呼吸道上皮和通过其受体ST2先天淋巴样细胞（劳工公约）的激活IL-33的释放，输入从那些劳工公约2细胞因子的释放和TH2细胞，肥大细胞脱颗粒，大容量的本地B细胞活化和IgE的形成，和最后嗜酸性粒细胞引力与细胞外陷阱随后释放，增加了上皮损伤和通过形成夏科 - 莱顿晶体有助于疾病的持久性是由金黄色葡萄球菌的粘膜免疫的操作的最突出的特点。综上所述，金黄色葡萄球菌声称在严重的气道炎症的编排和在当前和未来的疾病严重程度显着的作用。在这次审查中，我们在这一领域的讨论当前的知识，并概述了未来的研究，充分了解金黄色葡萄球菌及其蛋白对稿件最近已经接受了在欧洲呼吸杂志出版asthma.FootnotesThis影响需求。 It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Bachert has nothing to disclose.Conflict of interest: Dr. Humbert reports personal fees from Astrazeneca, personal fees from GSK, personal fees from Merck, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work.Conflict of interest: NAH has received honoraria for serving on advisory boards or as consultant from Novartis, Genentech, Roche, Novartis, AstraZeneca, GSK, Gossamer Bio and Boehringer Ingelheim. His institution received research grant support on his behalf from GSK, Boehringer Ingelheim, AstraZenecaConflict of interest: Dr. Zhang has nothing to disclose.Conflict of interest: Dr. holgate has nothing to disclose.Conflict of interest: Dr. Buhl has nothing to disclose.Conflict of interest: Dr. Bröker has nothing to disclose.