@article {Bachert1901592，作者= {Bachert，克劳斯和亨伯特，Marc和Hanania，尼古拉A.和Zhang，楠和霍尔盖特，Stephen和布尔，罗兰和Br {\“○} KER，巴巴拉M.}，标题= {金黄色葡萄球菌和IgE的诱导肠毒素在哮喘：当前知识}，elocation-ID = {1901592}，年= {} 2020，DOI = {10.1183 / 13993003.01592-2019}，出版商= {欧洲呼吸学会}，抽象= {188bet官网地址虽然免疫球蛋白E为早发性的显着的生物标志物，其水平通常在非过敏性迟发性哮喘升高。但是，IgE的表达在后者的图案大多是多克隆的，与特异性IgE低或低于检测水平虽然是增加总IgE。在迟发性重度哮喘患者中，特异性IgE对葡萄球菌肠毒素（SE-IgE）的可能频繁在血清中被检测到，并且已经与哮喘有关的，与在肺由住院定义重度哮喘，口服类固醇的使用和减少功能。近日，SE-IgE的证明，甚至预测ŧ他的发展与未来十年发作严重的哮喘。金黄色葡萄球菌在操纵通过它的蛋白质的各种级别，包括超抗原，丝氨酸蛋白酶样蛋白（声压级），或蛋白A（SPA）和可能的其他气道粘膜免疫。从呼吸道上皮和通过其受体ST2先天淋巴样细胞（劳工公约）的激活IL-33的释放，输入从那些劳工公约2细胞因子的释放和TH2细胞，肥大细胞脱颗粒，大容量的本地B细胞活化和IgE的形成，和最后嗜酸性粒细胞引力与细胞外陷阱随后释放，增加了上皮损伤和通过形成夏科 - 莱顿晶体有助于疾病的持久性是由金黄色葡萄球菌的粘膜免疫的操作的最突出的特点。综上所述，金黄色葡萄球菌声称在严重的气道炎症的编排和在当前和未来的疾病严重程度显着的作用。 In this review, we discuss current knowledge in this field and outline the needs for future research to fully understand the impact of S. aureus and its proteins on asthma.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Bachert has nothing to disclose.Conflict of interest: Dr. Humbert reports personal fees from Astrazeneca, personal fees from GSK, personal fees from Merck, personal fees from Novartis, personal fees from Roche, personal fees from Sanofi, personal fees from Teva, outside the submitted work.Conflict of interest: NAH has received honoraria for serving on advisory boards or as consultant from Novartis, Genentech, Roche, Novartis, AstraZeneca, GSK, Gossamer Bio and Boehringer Ingelheim. His institution received research grant support on his behalf from GSK, Boehringer Ingelheim, AstraZenecaConflict of interest: Dr. Zhang has nothing to disclose.Conflict of interest: Dr. holgate has nothing to disclose.Conflict of interest: Dr. Buhl has nothing to disclose.Conflict of interest: Dr. Br{\"o}ker has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2020/01/03/13993003.01592-2019}, eprint = {//www.qdcxjkg.com/content/early/2020/01/03/13993003.01592-2019.full.pdf}, journal = {European Respiratory Journal} }