@article {Eastwood1901320，笔者= {伊斯特伍德，彼得R.和巴恩斯，MAREE和麦凯，斯图尔特G.和惠特利，约翰R.和希尔曼，大卫R.和Nguy {\ ^ E} N，徐{\ ^ A}正兰和Lewis，Richard和坎贝尔，马修C.和P {\'E} Telle公司，鲍里斯和Walsh，珍H.和Jones，安德鲁C.和帕尔梅，卡斯滕E.和BIZON，阿兰和Meslier，Nicole和Bertolus，氯苯{\ 'E}和麦迪逊，凯瑟琳J.和Laccourreye，Laurent和RAUX纪尧姆和Denoncin，Katleen和阿塔利，缬氨酸{\' E} RIE和Gagnadoux，星期五{\ 'E} d {\' 电子} RIC和Launois，桑德琳H.}，标题= {双侧舌下神经刺激治疗成人阻塞性睡眠呼吸暂停}，体积= {55}，数= {1}，elocation-ID = {1901320}，年= {2020的通过颏舌肌激活}，DOI = {10.1183 / 13993003.01320-2019}，出版商= {188bet官网地址欧洲呼吸协会}，抽象= {背景和目标舌下神经刺激（HNS）降低阻塞性睡眠呼吸暂停（OSA）的严重程度和降低上气道塌陷。本研究评估在6个月的安全性和有效性植入后一种新颖的器件经由通过从外部佩戴的单元激活的小植入电极递送双边HNS的，以治疗OSA：所述杰尼奥{\ texttrademark} system.Methods本前瞻性，开标签，非随机，单组的治疗研究在八个中心在三个国家（澳大利亚，法国和英国）进行。主要成果是在呼吸暂停{\ textendash}低通气指数（AHI）设备相关的严重不良事件和变化发生。次要结果是在4 \％氧饱和度指数（ODI）的变化。其他成果包括嗜睡，生活质量，打鼾和设备使用的措施。该试验用ClinicalTrials.gov注册，编号NCT03048604.Results 22出27名植入参与者（63 \％男性，年龄55.9 {\ textpm}12.0年，身体质量指数（BMI）27.4 {\ textpm}3.0公斤{\ textperiodcentered的} M-2）完成的协议。 At 6 months BMI was unchanged (p=0.85); AHI decreased from 23.7{\textpm}12.2 to 12.9{\textpm}10.1 events{\textperiodcentered}h-1, a mean change of 10.8 events{\textperiodcentered}h-1 (p\<0.001); and ODI decreased from 19.1{\textpm}11.2 to 9.8{\textpm}6.9 events{\textperiodcentered}h-1, a mean change of 9.3 events{\textperiodcentered}h-1 (p\<0.001). Daytime sleepiness (Epworth Sleepiness Scale; p=0.01) and sleep-related quality of life (Functional Outcomes of Sleep Questionnaire-10; p=0.02) both improved significantly. The number of bed partners reporting loud, very intense snoring, or leaving the bedroom due to participant snoring decreased from 96\% to 35\%. 91\% of participants reported device use \>5 days per week, and 77\% reported use for \>5 h per night. No device-related serious adverse events occurred during the 6-month post-implantation period.Conclusions Bilateral HNS using the Genio{\texttrademark} system reduces OSA severity and improves quality of life without device-related complications. The results are comparable with previously published HNS systems despite minimal implanted components and a simple stimulation algorithm.A new method of hypoglossal nerve stimulation to treat sleep apnoea does so bilaterally via an implanted neurostimulator activated externally. Its simplicity and relative non-invasiveness have not compromised its effectiveness relative to older methods. http://bit.ly/2lDCeif}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/55/1/1901320}, eprint = {//www.qdcxjkg.com/content/55/1/1901320.full.pdf}, journal = {European Respiratory Journal} }