电子T1预后fac RT老杂志文章tors associated with long-term mortality in 1445 patients with nontuberculous mycobacterial pulmonary disease: a 15-year follow-up study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 1900798 DO 10.1183/13993003.00798-2019 VO 55 IS 1 A1 Jhun, Byung Woo A1 Moon, Seong Mi A1 Jeon, Kyeongman A1 Kwon, O Jung A1 Yoo, Heejin A1 Carriere, Keumhee C. A1 Huh, Hee Jae A1 Lee, Nam Yong A1 Shin, Sung Jae A1 Daley, Charles L. A1 Koh, Won-Jung YR 2020 UL //www.qdcxjkg.com/content/55/1/1900798.abstract AB Limited data are available regarding the prognostic factors for patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the prognostic factors associated with long-term mortality in NTM-PD patients after adjusting for individual confounders, including aetiological organism and radiological form.A total of 1445 patients with treatment-naïve NTM-PD who were newly diagnosed between July 1997 and December 2013 were included. The aetiological organisms were as follows: Mycobacterium avium (n=655), M. intracellulare (n=487), M. abscessus (n=129) and M. massiliense (n=174). The factors associated with mortality in NTM-PD patients were analysed using a multivariable Cox model after adjusting for demographic, radiological and aetiological data.The overall 5-, 10- and 15-year cumulative mortality rates for the NTM-PD patients were 12.4%, 24.0% and 36.4%, respectively. On multivariable analysis, the following factors were significantly associated with mortality in NTM-PD patients: old age, male sex, low body mass index, chronic pulmonary aspergillosis, pulmonary or extrapulmonary malignancy, chronic heart or liver disease and erythrocyte sedimentation rate. The aetiological organism was also significantly associated with mortality: M. intracellulare had an adjusted hazard ratio (aHR) of 1.40, 95% CI 1.03–1.91; M. abscessus had an aHR of 2.19, 95% CI 1.36–3.51; and M. massiliense had an aHR of 0.99, 95% CI 0.61–1.64, compared to M. avium. Mortality was also significantly associated with the radiological form of NTM-PD for the cavitary nodular bronchiectatic form (aHR 1.70, 95% CI 1.12–2.59) and the fibrocavitary form (aHR 2.12, 95% CI 1.57–3.08), compared to the non-cavitary nodular bronchiectatic form.Long-term mortality in patients with NTM-PD was significantly associated with the aetiological NTM organism, cavitary disease and certain demographic characteristics.The long-term mortality of patients with nontuberculous mycobacterial pulmonary disease was significantly associated with the aetiological organism, cavitary disease and certain demographic characteristics http://bit.ly/2kyXTHT