％0期刊文章％A Holguin，Fernando％A Cardet，Juan Carlos％A Chung，Kian Fan％A潜水员，Sarah％Ferreira，Diogenes S.％A Fitzpatrick，Anne％A Gaga，Mina％kellermeyer，Liz％aKhurana，Sandhya％A Knight，Shandra％A McDonald，Vanessa M.％A Morgan，Rebecca L.％A Ortega，Victor E.％A Rigau，David％A子塔，Padmaja％A Tonia，Thomy％A Adcock，Ian M.。％BLEEKER，Eugene R.％A Brighling，Chris％A Boulet，Louis-Plippe％A Cabana，Michael％A Castro，Mario％A Chanez，Pascal％的陪同，Adnan％A Djukanovic，Ratko％A Frey，URS％afrankemölle，贝蒂％a gibson，彼得％a hamerlijnck，dominique％a jarjour，nizar％akonno，satoshi％a shen，huahao％的灌木，粗糙的粗糙，安迪％t管理严重哮喘：欧洲呼吸系统社会/美国胸部社会指南％D 2020％R 10.1183 / 13993003.00588-2019％J欧洲呼吸期刊％P 1900588％v 55％n 1％x本文件为严重哮喘的管理提供临床建议。综合证据合成，包括荟萃分析，总结了与欧洲呼吸协会/美国胸部社会工作队有关的所有可用证据。188bet官网地址使用成绩（建议，评估，开发和评估）方法等级评估了证据，结果总结了证据简介。讨论了证据合成并通过哮喘专家的多学科工作队制定的建议，他提出了关于六个具体问题的具体建议。在考虑到所需和不良后果的平衡后，证据质量，各种干预的可行性和可接受性，工作队提出了以下建议：1）建议使用抗白细胞蛋白（IL）-5和抗IL-5受体α对于严重的不受控制的成人嗜酸性嗜酸性哮喘表型; 2) suggest using a blood eosinophil cut-point ≥150 μL−1 to guide anti-IL-5 initiation in adult patients with severe asthma; 3) suggest considering specific eosinophil (≥260 μL−1) and exhaled nitric oxide fraction (≥19.5 ppb) cut-offs to identify adolescents or adults with the greatest likelihood of response to anti-IgE therapy; 4) suggest using inhaled tiotropium for adolescents and adults with severe uncontrolled asthma despite Global Initiative for Asthma (GINA) step 4–5 or National Asthma Education and Prevention Program (NAEPP) step 5 therapies; 5) suggest a trial of chronic macrolide therapy to reduce asthma exacerbations in persistently symptomatic or uncontrolled patients on GINA step 5 or NAEPP step 5 therapies, irrespective of asthma phenotype; and 6) suggest using anti-IL-4/13 for adult patients with severe eosinophilic asthma and for those with severe corticosteroid-dependent asthma regardless of blood eosinophil levels. These recommendations should be reconsidered as new evidence becomes available.The ERS/ATS Task Force makes recommendations on the use of novel therapies for severe asthma, specifically biologicals for type 2 high asthma, and antimuscarinic agents and macrolides, as well as on biomarkers for predicting treatment response http://bit.ly/2kZLRaD %U //www.qdcxjkg.com/content/erj/55/1/1900588.full.pdf