PT - 日刊文AU - 王，章子怡AU - 比尔，Elianna A. AU - 斯瓦米纳坦，阿帕娜AU - 帕里克，基尚AU - Nouls，约翰AU - 他，沐非盟 - Mammarappallil，约瑟夫G. AU - 罗盛AU -Driehuys，跋AU - Rajagopal，苏达TI - 10.1183 / 13993003.00831-2019 DP - - 多元心肺疾病都与不同的氙磁共振成像签名相关联的AID 2019 12月1 TA - 欧洲呼吸杂志PG - 1900831 VI - 54 IP - 6 4099 -//www.qdcxjkg.com/content/54/6/1900831.short 4100 - //www.qdcxjkg.com/content/54/6/1900831.full SO - 欧洲呼吸J2019 12月1;54 AB - 背景随着越来越多的患者表现出伴随心脏和肺疾病，的标准的诊断标准的限制更频繁地遇到。在这里，我们应用无创129Xe核磁共振成像（MRI）和光谱来标识唯一与慢性阻塞性肺疾病（COPD），特发性肺纤维化（IPF），左心脏衰竭（LHF）相关的区域天然气输送减值模式和血流动力学和肺动脉高压（PAH）。方法健康志愿者（N = 23）和COPD患者（N = 8），IPF（N = 12），LHF（N = 6）和PAH（N = 10）经历129Xe气体传送成像和动态光谱。对于每位患者，产生了描绘的通风，屏障摄取（129Xe溶解在间质组织）和红血细胞（RBC）转移（129Xe溶解在红细胞）的三维地图。动态129Xe光谱法用于量化在RBC信号振幅心源性振荡和与健康志愿者相比频率shift.Results，显示出所有患者组的通风和RBC转移（二者P≤0.01）降低。与所有其他组（均为P≤0.02）相比COPD患者表现出更多的通风和阻隔缺陷。 In contrast, IPF patients demonstrated elevated barrier uptake compared with all other groups (p≤0.007), and increased RBC amplitude and shift oscillations compared with healthy volunteers (p=0.007 and p≤0.01, respectively). Patients with COPD and PAH both exhibited decreased RBC amplitude oscillations (p=0.02 and p=0.005, respectively) compared with healthy volunteers. LHF was distinguishable from PAH by enhanced RBC amplitude oscillations (p=0.01).Conclusion COPD, IPF, LHF and PAH each exhibit unique 129Xe MRI and dynamic spectroscopy signatures. These metrics may help with diagnostic challenges in cardiopulmonary disease and increase understanding of regional lung function and haemodynamics at the alveolar–capillary level.Different heart and lung diseases exhibit unique 129Xe MRI and spectroscopy signatures. These may help differentiate cardiopulmonary disease and increase our understanding of regional lung function and haemodynamics at the alveolar–capillary level. http://bit.ly/2lZCsQy