@article {Wang1900831，笔者= {王，章子怡和比尔，Elianna A.和斯瓦米纳坦，阿帕娜和帕瑞克，基尚和Nouls，约翰和他，穆Mammarappallil，约瑟夫G.和罗盛和Driehuys，巴斯蒂安和Rajagopal，苏达}，标题= {多元心肺疾病都与不同的氙磁共振成像签名}，体积= {54}，数= {6}，elocation-ID = {1900831}，年= {2019}，DOI = {10.1183相关联/13993003.00831-2019}，出版商= {欧洲呼吸协会}，188bet官网地址抽象= {背景随着越来越多的患者表现出伴随心脏和肺疾病，更经常遇到的标准的诊断标准的局限性。在这里，我们应用无创129Xe核磁共振成像（MRI）和光谱来标识唯一与慢性阻塞性肺疾病（COPD），特发性肺纤维化（IPF），左心脏衰竭（LHF）相关的区域天然气输送减值模式和血流动力学和肺动脉高压（PAH）。方法健康志愿者（N = 23）和COPD患者（N = 8），IPF（N = 12），LHF（N = 6）和PAH（N = 10）经历129Xe气体传送成像和动态光谱。对于每位患者，产生了描绘的通风，屏障摄取（129Xe溶解在间质组织）和红血细胞（RBC）转移（129Xe溶解在红细胞）的三维地图。动态129Xe光谱法用于量化在RBC信号振幅心源性振荡和与健康志愿者相比频率shift.Results，显示出所有患者组的通风和RBC转移（二者p <= 0.01）降低。与所有其他组相比COPD患者表现出更多的通风和阻隔缺陷（二者p <= 0.02）。与此相反，IPF患者表现出升高的阻挡摄取与所有其他组（P <= 0.007）相比较，并且与健康志愿者（P = 0.007和p <= 0.01）相比，增加RBC振幅和移振荡。 Patients with COPD and PAH both exhibited decreased RBC amplitude oscillations (p=0.02 and p=0.005, respectively) compared with healthy volunteers. LHF was distinguishable from PAH by enhanced RBC amplitude oscillations (p=0.01).Conclusion COPD, IPF, LHF and PAH each exhibit unique 129Xe MRI and dynamic spectroscopy signatures. These metrics may help with diagnostic challenges in cardiopulmonary disease and increase understanding of regional lung function and haemodynamics at the alveolar{\textendash}capillary level.Different heart and lung diseases exhibit unique 129Xe MRI and spectroscopy signatures. These may help differentiate cardiopulmonary disease and increase our understanding of regional lung function and haemodynamics at the alveolar{\textendash}capillary level. http://bit.ly/2lZCsQy}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/6/1900831}, eprint = {//www.qdcxjkg.com/content/54/6/1900831.full.pdf}, journal = {European Respiratory Journal} }