RT期刊文章SR电子T1全国性分析儿童和青少年治疗结果常规治疗荷兰结核病JF欧洲呼吸杂志Jo EUR Respir J FD欧洲呼吸学会SP 1901402 Do 10.1183 / 13993003.01402-2019 VO 54是6 A1 Gafar，Fajri188bet官网地址A1 Van'tboveneind-Vrubleuskaya，Natasha A1 Akkerman，Onno W. A1 Wilffert，Bob A1 Alffenaar，Jan-Willem C. Yr 2019 UL //www.qdcxjkg.com/content/54/6/1901402.abstract ab背景作为弱势群体，儿童和青少年（TB）面临着许多挑战，甚至那些居住在低结核病发病国家的挑战。我们的旨在评估与结核病治疗结果相关的因素，允许更多地诊断出于支持这一人口的措施。诊断，使用全国范围内监测数据库进行回顾性队列研究，在荷兰的TB治疗的儿童和青少年（年龄0-18岁）中进行从1993年到2018年。逻辑回归分析用于估计调整后的差距（AOR）对于相关的死亡率和对后续行动（LTFU）的丧失的相关因素。结果在3253名符合条件的患者中，94.4％（95.9％和92.8患者％青少年）固化或完成处理，治疗期间的0.7％，4.9％是LTFU。没有报告的治疗失败。死亡危险因素包括2-4岁儿童（AOR 10.42），中枢神经系统TB（AOR 5.14），栗色结核病（AOR 10.25），HIV共感染（AOR 8.60），重新治疗的TB病例（AOR 10.12）和药物诱导的肝损伤（AOR 6.50）。主动案例发现是死亡的保护因素（AOR 0.13）。LTFU的风险因素是15-18岁的青少年（AOR 1.91），非法移民（AOR 4.28），城市住所（AOR 1.59），TB接触的未知历史（AOR 1.99），耐药TB（AOR 2.31），单一 adverse drug reaction (aOR 2.12), multiple adverse drug reactions (aOR 7.84) and treatment interruption >14 days (aOR 6.93). Treatment in recent years (aOR 0.94) and supervision by public health nurses (aOR 0.14) were protective factors of LTFU.Conclusion Highly successful treatment outcomes were demonstrated in children and adolescents routinely treated for TB. Special attention should be given to specific risk groups to improve treatment outcomes.High success rates for TB treatment were achieved in children and adolescents in the Netherlands. To further optimise care in this population, several risk factors particularly associated with mortality and loss to follow-up have been identified. http://bit.ly/2lLJRTC