TY - T1的全国范围内的分析治疗结果在儿童和青少年经常治疗肺结核在荷兰JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01402 -2019欧元六世- 54 - 6 SP - 1901402 AU Gafar Fajri AU - van Boveneind-Vrubleuskaya,娜塔莎盟——Akkerman应该w . AU - Wilffert,鲍勃盟——Alffenaar Jan-Willem c Y1 - 2019/12/01 UR - //www.qdcxjkg.com/content/54/6/1901402.abstract N2 -背景脆弱人群,儿童和青少年与结核病(TB)正面临着许多挑战,即使是那些生活在低结核发病率国家。我们的目的是评估与结核病治疗结果相关的因素，以便在确诊后采取更有针对性的干预措施来支持这一人群。方法采用全国监测数据库，对1993年至2018年在荷兰接受结核病治疗的儿童和青少年(0-18岁)进行回顾性队列研究。采用Logistic回归分析估计死亡率和随访损失相关因素的校正优势比(aOR)。结果3253例患者中，94.4%(95.9%儿童和92.8%青少年)治愈或完成治疗，0.7%在治疗期间死亡，4.9%为LTFU。没有治疗失败的报告。死亡危险因素为2 ~ 4岁儿童(aOR 10.42)、中枢神经系统结核(aOR 5.14)、军事结核(aOR 10.25)、HIV合并感染(aOR 8.60)、再治疗结核(aOR 10.12)和药物性肝损伤(aOR 6.50)。主动病例发现是死亡的保护因素(aOR 0.13)。LTFU的危险因素为:15 ~ 18岁青少年(aOR 1.91)、非法移民(aOR 4.28)、城市户籍(aOR 1.59)、结核接触史不明(aOR 1.99)、耐药结核(aOR 2.31)、单一药物不良反应(aOR 2.12)、多重药物不良反应(aOR 7.84)和中断治疗14天(aOR 6.93)。 Treatment in recent years (aOR 0.94) and supervision by public health nurses (aOR 0.14) were protective factors of LTFU.Conclusion Highly successful treatment outcomes were demonstrated in children and adolescents routinely treated for TB. Special attention should be given to specific risk groups to improve treatment outcomes.High success rates for TB treatment were achieved in children and adolescents in the Netherlands. To further optimise care in this population, several risk factors particularly associated with mortality and loss to follow-up have been identified. http://bit.ly/2lLJRTC ER -