TY - JOUR T1 -脂肪性呼吸道:阻塞性疾病的JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00857 -2019欧元六世- 54 - 6 SP - 1900857 AU -艾略特,约翰·g·非盟-多诺万,格雷厄姆·m·王盟——金伯利漫画盟——绿色,弗朗西斯H.Y. AU -詹姆斯,艾伦•l . AU -高贵Peter B. Y1 - 2019/12/01 UR - //www.qdcxjkg.com/content/54/6/1900857.abstract N2 -流行病学研究报告称，超重或肥胖哮喘患者的疾病比健康体重者更严重。我们推测肥胖患者气道壁内脂肪组织的积累可能与气道病理有关。我们的目的是确定有无哮喘个体气道壁内脂肪组织与体重指数(BMI)之间的关系。从对照组(n=15)、非致命性(n=21)和致命性(n=16)哮喘病例的死后肺部分层取样横气道切片。评估气道脂肪组织、气道重塑与炎症的关系。气道壁和脂肪组织的面积用点计数法估算，用基底膜周长(Pbm)每毫米的面积表示。嗜酸性粒细胞和中性粒细胞的数量用面积密度表示。BMI范围在15 - 45 kg·m - 2之间，非致命性哮喘患者BMI更大(p;0.05)。 Adipose tissue was identified in the outer wall of large airways (Pbm >6 mm), but was rarely seen in small airways (Pbm <6 mm). Adipose tissue area correlated positively with eosinophils and neutrophils in fatal asthma (Pbm >12 mm, p<0.01), and with neutrophils in control subjects (Pbm >6 mm, p=0.04).These data show that adipose tissue is present within the airway wall and is related to BMI, wall thickness and the number of inflammatory cells. Therefore, the accumulation of airway adipose tissue in overweight individuals may contribute to airway pathophysiology.In individuals with elevated BMI, adipose tissue accumulates within the airway wall, correlates with greater wall thickness and airway inflammation and represents a new mechanism for airway pathophysiology in obese asthmatic patients http://bit.ly/2maDoSp ER -