@Article {Elliot1900857，作者= {Elliot，John G.和Donovan，Graham M.和Wang，Kimberley C.W.和Green，Francis H.Y.詹姆斯（James），艾伦（Alan L.）和诺布尔（Noble），彼得·B（Peter B.）}，doi = {10.1183/13993003.00857-2019}，Publisher = {欧洲188bet官网地址呼吸社会}，摘要= {流行病学研究报告，超重或肥胖的哮喘患者比健康体重的疾病更为严重。我们假设，超重患者可能发生脂肪组织在气道壁内的积累，并有助于气道病理学。我们的目的是确定有或没有哮喘的个体中气道壁中的脂肪组织与体重指数（BMI）之间的关系。横向气道切片是从对照组的验尸肺（n = 15）和非致命（n = 21）和致命（n = 16）哮喘的病例。评估了气道脂肪组织，重塑和炎症之间的关系。通过点计数估算气道壁和脂肪组织的区域，并表示为每毫米地下膜周长（PBM）面积。嗜酸性粒细胞和嗜中性粒细胞的数量表示为面积密度。BMI范围为15至45 kg {\ textperiodeDectred} M-2，在非致命哮喘病例中更大（P \ <0.05）。在大气道（PBM \> 6 mm）的外壁中鉴定出脂肪组织，但在小气道（PBM \ <6 mm）中很少见。 Adipose tissue area correlated positively with eosinophils and neutrophils in fatal asthma (Pbm \>12 mm, p\<0.01), and with neutrophils in control subjects (Pbm \>6 mm, p=0.04).These data show that adipose tissue is present within the airway wall and is related to BMI, wall thickness and the number of inflammatory cells. Therefore, the accumulation of airway adipose tissue in overweight individuals may contribute to airway pathophysiology.In individuals with elevated BMI, adipose tissue accumulates within the airway wall, correlates with greater wall thickness and airway inflammation and represents a new mechanism for airway pathophysiology in obese asthmatic patients http://bit.ly/2maDoSp}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/6/1900857}, eprint = {//www.qdcxjkg.com/content/54/6/1900857.full.pdf}, journal = {European Respiratory Journal} }