TY -的T1 - CPAP疗法的依从性不佳的阻塞性睡眠呼吸暂停的症状:随机、双盲、对照试验JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.01526 -2019欧元SP - 1901526 AU Gaisl托马斯盟——Rejmer Protazy AU -泰尔,Sira AU -海丽,莎拉·r . AU - Osswald进行,马丁AU -鲁斯,马格达雷娜盟——布洛赫,康拉德•e . AU,斯特拉德林John r . AU -科勒,马尔科姆Y1 - 2019/01/01 UR - //www.qdcxjkg.com/content/early/2019/12/04/13993003.01526 - 2019. -抽象N2 -介绍持续气道正压(CPAP)是目前的首选治疗阻塞性睡眠呼吸暂停(OSA)患者嗜睡,然而,坚持经常被认为是次优的。我们调查的影响,次优CPAP-usage阻塞性睡眠呼吸暂停患者的客观和主观睡眠参数。材料和方法在这2周,平行,双盲、随机对照试验我们注册是严重阻塞性睡眠呼吸暂停综合症患者过度预处理白天嗜睡(埃普沃思嗜睡量表(ESS)的分数在10分)曾CPAP依从性不佳在至少12个月(平均每晚使用时间3 - 4小时)。患者通过最小化分配开始CPAP (“sham-CPAP”)或继续CPAP (therapeutic-CPAP)。与历史先验贝叶斯分析计算后验概率的优势。结果在2016年5月,2018年11月,57例(60±8年,79%的男性,93%的白人)在总分配,和52完成这项研究在每个臂(50%)包括在最终的分析中。未经调整的ESS-score增加+ 2.4分(95% CI + 0.6 + 4.2;p = 0.01) sham-CPAP-group相比继续CPAP治疗。CPAP治疗要优于假CPAP的概率是90.4%,ESS为收缩90.1%,80.3%为舒张压。结论严重阻塞性睡眠呼吸暂停综合症患者和白天嗜睡仍得到实质性受益CPAP依从性不佳,虽然不如他们会如果他们坚持。 Whether a similar statement can be made for even lower adherence levels remains to be established in future trials.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Gaisl reports personal fees from Bayer AG (consulting), outside the submitted work.Conflict of interest: Dr. Rejmer has nothing to disclose.Conflict of interest: Dr. Thiel has nothing to disclose.Conflict of interest: Dr. Haile has nothing to disclose.Conflict of interest: Dr. Osswald has nothing to disclose.Conflict of interest: Dr. Roos has nothing to disclose.Conflict of interest: Dr. Bloch has nothing to disclose.Conflict of interest: Dr. Stradling reports personal fees from Bayer AG, personal fees from ResMed, outside the submitted work.Conflict of interest: Dr. Kohler reports personal fees from Bayer AG, grants from University of Zurich, grants from Lunge Zurich, outside the submitted work. ER -