TY - JOUR T1 - hiv相关结核病、结核病- iris和强的松对肺功能的影响JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01692- 1901692 AU - Stek, Cari AU - Allwood, Brian AU - Du Bruyn, Elsa AU - Buyze, Jozefien AU - Schutz, Charlotte AU - Thienemann, Friedrich AU - Lombard, Adele AU - Wilkinson, Robert J. AU - Meintjes, Graeme AU - lyen，Lutgarde Y1 - 2019/01/01 UR - //www.qdcxjkg.com/content/early/2019/12/04/13993003.01692-2019.abstract N2 -结核病治疗后残余肺损害是常见的。艾滋病毒相关结核病患者的肺功能数据很少，特别是在结核病相关免疫重建炎症综合征(TB-IRIS)和预防性强的松的背景下。我们的目的是确定CD4计数≤100细胞·μL−1的hiv相关结核病患者肺功能异常的患病率，并评估预防性强的松和TB-IRIS的发展对肺损害的影响。我们对PredART试验的参与者在基线(第0周)、第4周、第12周和第28周进行了肺活量测定、6分钟步行试验和胸部x线摄影，该试验评估了开始抗逆转录病毒治疗的hiv相关结核病患者服用强的松28天预防TB-IRIS。153名参与者在一个或多个时间点进行了肺活量测定和/或六分钟步行测试。66%的参与者在第0周和第28周时出现异常肺活量测量;用力肺活量低是最常见的异常。胸部x线片显示大多数参与者很少或没有异常。在第4周，使用强的松导致6分钟步行距离增加42米，预测用力呼气量在1秒内增加4.9%;从第12周开始，这些差异不再有显著差异。 TB-IRIS did not significantly impair lung function outcome.Residual pulmonary impairment is common in HIV-associated tuberculosis. In patients with low CD4 counts, neither prophylactic prednisone as used in our study nor the development of TB-IRIS significantly affected week 28 pulmonary outcome.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Dr. Stek has nothing to disclose.Conflict of interest: Dr. Allwood has nothing to disclose.Conflict of interest: Dr. Du Bruyn has nothing to disclose.Conflict of interest: Dr. Buyze has nothing to disclose.Conflict of interest: Dr. Schutz has nothing to disclose.Conflict of interest: Dr. Thienemann has nothing to disclose.Conflict of interest: Dr. Lombard has nothing to disclose.Conflict of interest: Dr. Wilkinson reports grants from Wellcome, grants from UK research and Innovation, grants from National Institutes of Health, grants from Foundation for the National Institues of Health, grants from European and Developing Countries Clinical Trials Partnership, during the conduct of the study.Conflict of interest: Dr. Meintjes has nothing to disclose.Conflict of interest: Dr. Lynen has nothing to disclose. ER -