TY -的T1 -烧热了的媒体:downregulation of PRMT1 for long-lasting effects of bronchial thermoplasty JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.01898-2019 VL - 54 IS - 6 SP - 1901898 AU - Rahmawati, Siti Farah AU - Gosens, Reinoud Y1 - 2019/12/01 UR - //www.qdcxjkg.com/content/54/6/1901898.abstract N2 - Asthma is broadly defined as a group of clinical symptoms with reversible expiratory airflow limitation or bronchial hyperresponsiveness with or without airway inflammation [1]. These symptoms are associated with airway remodelling, particularly in severe asthma patients, which is characterised by alterations of the tissue structure and cells within the airway, including increased submucosal extracellular matrix deposition, reticular basement membrane (RBM) thickening, airway smooth muscle (ASM) hyperplasia and hypertrophy, bronchial microvascular remodelling and mucous cell metaplasia [2–4].An epithelial–mesenchymal interaction governed by HSP60-regulated PRMT1 expression regulates airway remodelling and is reversed by bronchial thermoplasty http://bit.ly/2NDCKGW ER -