@article {Wooding1901495作者={丹尼斯·j·伍丁和最小Hyung Ryu挂李和尼尔·e·亚历克西斯奥尔加佩纳和克里斯Carlsten},编辑= {},title ={严重空气污染暴露改变人类中性粒细胞在不吸烟者和高危},elocation-id = {1901495} = {2019}, doi ={10.1183/13993003.01495 -2019},出版商={欧洲呼吸学会},文摘={室外空气污染暴露增加COPD住院治疗上,并且可能导致慢性阻塞性肺病的发展。188bet官网地址危害的机制,和高危人群的程度更易感,并不完全理解。肺中性粒细胞招募到柴油机尾气(DE)暴露后,模型与交通有关的空气污染(陷阱),但他们在这个响应未知功能的作用。这个控制人类接触交叉研究的目的是评估急性DE暴露对中性粒细胞功能的影响不吸烟者和高危人群,支持额外的体外研究。18个参与者,包括不吸烟者(N = 7)烟(N = 4),和轻中度慢性阻塞性肺病患者(N = 7),暴露在德和过滤空气在不同场合(FA) 2 h,在血液和中性粒细胞功能(0 h和24 h后)和支气管肺泡灌洗(24小时后)评估。FA相比,德接触减少循环带细胞的比例在0 h,夸大了在慢性阻塞性肺病患者。DE嗜中性粒细胞的数量增加细胞外陷阱(网)在肺的参与者。慢性阻塞性肺病患者增加外围中性粒细胞激活后德。体外,暂停了柴油机排气微粒也增加了网以孤立的中性粒细胞的数量。我们建议网络形成作为一个可能的陷阱暴露影响气道病理生理学机制。此外,慢性阻塞性肺病患者可能更容易暴露后激活炎症状态。 This is the first controlled human TRAP exposure study directly comparing at-risk phenotypes (COPD and ex-smoker) with lower-risk (never-smokers), elucidating the human susceptibility spectrum.FootnotesThis manuscript has recently been accepted for publication in the European Respiratory Journal. It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article.Conflict of interest: Ms. Wooding reports grants from WorkSafeBC, grants from Canadian Institutes of Health Research, during the conduct of the study.Conflict of interest: Mr. Ryu reports grants from Canadian Respiratory Research Network, grants from WorkSafeBC, from Natural Sciences and Engineering Research Council of Canada, during the conduct of the study.Conflict of interest: Dr. Li reports grants from Sun Yat-sen University International Program Fund, grants from Chinese Government Scholarship, during the conduct of the study.Conflict of interest: Dr. Alexis has nothing to disclose.Conflict of interest: Dr. Pena has nothing to disclose.Conflict of interest: Dr. Carlsten reports grants from Canadian Respiratory Research Network, Canada Research Chairs Program, during the conduct of the study.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2019/11/26/13993003.01495-2019}, eprint = {//www.qdcxjkg.com/content/early/2019/11/26/13993003.01495-2019.full.pdf}, journal = {European Respiratory Journal} }