TY -的T1 Morphomolecular图案的肺间质性肺疾病neoangiogenesis JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00933 -2019欧元SP - 1900933 AU -马克西米利安Ackermann盟Helge鲜明的非盟-拉维尼娅Neubert AU -斯蒂芬妮·舒伯特AU -保罗Borchert盟Friedemann林茨AU -威利·l·瓦格纳盟Wolfram斯蒂勒非盟-马克Wielputz AU -安妮Hoefer AU -阿克塞尔Haverich AU - Steven J . Mentzer盟Harshit r·沙马克Kuehnel盟盟- Tobias Welte盟-丹尼Jonigk Y1 - 2019/01/01 UR - //www.qdcxjkg.com/content/early/2019/11/26/13993003.00933 - 2019. -抽象N2 -致病的血管生成在间质性肺病(ILD)的作用是有争议的。这项研究是第一个调查的空间复杂性的微血管结构和分子图案人类ILD的重要子集。我们的研究的目的是确定特定变异的人类ILD neoangiogenesis在三个常见的肺损伤模式。我们进行了综合和compartment-specific分析人类肺与摘要外植体,共24 NSIP AFE使用组织病理学,微血管腐蚀铸造、µCT-based容量分析,使用Nanostring以及免疫组织化学和基因表达分析评估remodeling-associated血管生成。Morphometrical评估血管直径和intervascular距离显示显著差异在典型neoangiogenesis改制的摘要、NSIP, AFE肺。同样,基因表达分析显示不同的和特定的血管生成配置文件摘要,NSIP AFE肺。而摘要肺显示更高的上游多血管密度和低密度病灶周边血管,NSIP AFE肺显示血管密集的肺泡间隔。NSIP血管重建和AFE的特点是著名intussusceptive neoangiogenesis,与摘要,萌芽的新船到纤维化的地区特点。基因表达的分子分析提供一个基础理解这些基本AFE差异和摘要,并洞察到相关的细胞功能。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。这些生产过程完成后,作者已经批准结果证明,本文将最新一期的ERJ在线。请打开或下载PDF查看这篇文章。Conflict of interest: Dr. Ackermann has no conflict/no disclosures.Conflict of interest: Dr. Stark has nothing to disclose.Conflict of interest: Dr. Neubert has nothing to disclose.Conflict of interest: Dr. Schubert has nothing to disclose.Conflict of interest: Dr. Borchert has nothing to disclose.Conflict of interest: Dr Linz has no conflict/no disclosuresConflict of interest: Dr. Wagner has nothing to disclose.Conflict of interest: Dr. Wielpütz reports grants from Boehringer Ingelheim, grants from Vertex Pharma, outside the submitted work.Conflict of interest: Anne Höfer has nothing to disclose.Conflict of interest: Dr. Haverich has nothing to disclose.Conflict of interest: Dr. Mentzer has nothing to disclose.Conflict of interest: Dr. Shah has nothing to disclose.Conflict of interest: Dr. Welte reports grants from German Ministry of Research and Education, during the conduct of the study; personal fees from Boehringer Ingelheim, personal fees from Roche, outside the submitted work.Conflict of interest: Dr. Jonigk has nothing to disclose.Conflict of interest: Dr. Stiller reports grants from German Federal Ministry of Education and Research (BMBF), during the conduct of the study.Conflict of interest: Dr. Kühnel has nothing to disclose. ER -