TY -的T1 Morphomolecular图案的肺间质性肺疾病neoangiogenesis JF -欧洲呼吸杂志》乔和J - 10.1183/13993003.00933 -2019欧元SP - 1900933 AU -阿克曼,马克西米利安非盟-斯塔克,Helge盟——Neubert拉维尼娅AU -舒伯特,斯蒂芬妮盟——Borchert Friedemann AU -瓦格纳,保罗•AU -林茨威利l . AU -斯蒂勒,Wolfram盟——Wielputz马克盟——Hoefer安妮盟——Haverich Axel盟——Mentzer Steven J . AU -沙Harshit r . AU - WelteTobias AU - Kuehnel, Mark AU - Jonigk, Danny Y1 - 2019/01/01 UR - //www.qdcxjkg.com/content/early/2019/11/26/13993003.00933-2019.abstract N2 -血管生成在间质性肺疾病(ILD)中的病理作用存在争议。本研究首次对人类ILD重要亚群微血管结构的空间复杂性和分子基序进行了研究。我们研究的目的是在三种常见的人肺间质纤维化肺损伤模式中确定新血管生成的特定变体。我们使用组织病理学、微血管腐蚀铸造、ct容量测定、Nanostring基因表达分析以及免疫组化技术对24例UIP、NSIP和AFE人类肺外植体进行了全面和间隔特异性分析，以评估重塑相关的血管生成。血管直径和血管间距离的形态测量评估显示，UIP、NSIP和AFE肺的特征重塑区新生血管生成有显著差异。同样，基因表达分析显示，UIP、NSIP和AFE肺中有不同和特异性的血管生成谱。而UIP肺显示较高的上游血管密度和较低的局灶周围血管密度，NSIP和AFE肺显示密集的肺泡间隔血管。NSIP和AFE的血管重构以显著的肠套叠新血管生成为特征，与UIP相反，UIP的特征是新血管进入纤维化区域。基因表达的分子分析为理解AFE和UIP之间的这些基本差异提供了基础，并深入了解相关的细胞功能。脚注:该手稿最近被《欧洲呼吸杂志》接受发表。在我们的制作团队进行编辑和排版之前，它以被接受的形式发表在这里。在完成这些生产过程并且作者批准了产生的证明之后，本文将转到最新一期的ERJ在线版。 Please open or download the PDF to view this article.Conflict of interest: Dr. Ackermann has no conflict/no disclosures.Conflict of interest: Dr. Stark has nothing to disclose.Conflict of interest: Dr. Neubert has nothing to disclose.Conflict of interest: Dr. Schubert has nothing to disclose.Conflict of interest: Dr. Borchert has nothing to disclose.Conflict of interest: Dr Linz has no conflict/no disclosuresConflict of interest: Dr. Wagner has nothing to disclose.Conflict of interest: Dr. Wielpütz reports grants from Boehringer Ingelheim, grants from Vertex Pharma, outside the submitted work.Conflict of interest: Anne Höfer has nothing to disclose.Conflict of interest: Dr. Haverich has nothing to disclose.Conflict of interest: Dr. Mentzer has nothing to disclose.Conflict of interest: Dr. Shah has nothing to disclose.Conflict of interest: Dr. Welte reports grants from German Ministry of Research and Education, during the conduct of the study; personal fees from Boehringer Ingelheim, personal fees from Roche, outside the submitted work.Conflict of interest: Dr. Jonigk has nothing to disclose.Conflict of interest: Dr. Stiller reports grants from German Federal Ministry of Education and Research (BMBF), during the conduct of the study.Conflict of interest: Dr. Kühnel has nothing to disclose. ER -