@article {Ackermann1900933作者={马克西米利安阿克曼和赫尔格·斯塔克,拉维尼娅Neubert斯蒂芬妮·舒伯特和保罗Borchert Friedemann林茨和威利·l·瓦格纳和Wolfram斯蒂勒和马克Wielp {\ " u} tz和安妮Hoefer Axel Haverich和Steven j . Mentzer Harshit r·沙阿和Tobias Welte和马克Kuehnel和丹尼Jonigk}, title = {Morphomolecular图案的肺间质性肺疾病neoangiogenesis}, elocation-id = {1900933} = {2019}, doi ={10.1183/13993003.00933 -2019},出版商={欧洲呼吸学会},文摘={致病的血管生成在间质性肺病(ILD)的作用是有争议的。188bet官网地址这项研究是第一个调查的空间复杂性的微血管结构和分子图案人类ILD的重要子集。我们的研究的目的是确定特定变异的人类ILD neoangiogenesis在三个常见的肺损伤模式。我们进行了综合和compartment-specific分析人类肺与摘要外植体,共24 NSIP AFE使用组织病理学,微血管腐蚀铸造、{\ textmu} CT-based容量分析,使用Nanostring以及免疫组织化学和基因表达分析评估remodeling-associated血管生成。Morphometrical评估血管直径和intervascular距离显示显著差异在典型neoangiogenesis改制的摘要、NSIP, AFE肺。同样,基因表达分析显示不同的和特定的血管生成配置文件摘要,NSIP AFE肺。而摘要肺显示更高的上游多血管密度和低密度病灶周边血管,NSIP AFE肺显示血管密集的肺泡间隔。NSIP血管重建和AFE的特点是著名intussusceptive neoangiogenesis,与摘要,萌芽的新船到纤维化的地区特点。基因表达的分子分析提供一个基础理解这些基本AFE差异和摘要,并洞察到相关的细胞功能。FootnotesThis手稿最近发表在《欧洲呼吸杂志》上。这里发表周全之前接受的形式排版,我们的生产团队。这些生产过程完成后,作者已经批准结果证明,本文将最新一期的ERJ在线。请打开或下载PDF查看这篇文章。Conflict of interest: Dr. Ackermann has no conflict/no disclosures.Conflict of interest: Dr. Stark has nothing to disclose.Conflict of interest: Dr. Neubert has nothing to disclose.Conflict of interest: Dr. Schubert has nothing to disclose.Conflict of interest: Dr. Borchert has nothing to disclose.Conflict of interest: Dr Linz has no conflict/no disclosuresConflict of interest: Dr. Wagner has nothing to disclose.Conflict of interest: Dr. Wielp{\"u}tz reports grants from Boehringer Ingelheim, grants from Vertex Pharma, outside the submitted work.Conflict of interest: Anne H{\"o}fer has nothing to disclose.Conflict of interest: Dr. Haverich has nothing to disclose.Conflict of interest: Dr. Mentzer has nothing to disclose.Conflict of interest: Dr. Shah has nothing to disclose.Conflict of interest: Dr. Welte reports grants from German Ministry of Research and Education, during the conduct of the study; personal fees from Boehringer Ingelheim, personal fees from Roche, outside the submitted work.Conflict of interest: Dr. Jonigk has nothing to disclose.Conflict of interest: Dr. Stiller reports grants from German Federal Ministry of Education and Research (BMBF), during the conduct of the study.Conflict of interest: Dr. K{\"u}hnel has nothing to disclose.}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/early/2019/11/26/13993003.00933-2019}, eprint = {//www.qdcxjkg.com/content/early/2019/11/26/13993003.00933-2019.full.pdf}, journal = {European Respiratory Journal} }