ty -jour t1-维持阿奇霉素会减少哮喘加重吗？单个参与者数据荟萃分析JF-欧洲呼吸杂志，Michelle au -Brusselle，Guy G. Au -Gibson，Peter G. Y1-2019/11/01 Ur -http：//www.qdcxjkg.com/content.com/content/54/54/5/1901381.ABSTRART哮喘治疗的重要目标。阿奇霉素的长期治疗可能有助于实现这一目标。我们的目的是进行系统的审查和个别参与者数据（IPD）荟萃分析，以检查阿奇霉素在减少哮喘中的恶化以及无嗜酸性哮喘哮喘，嗜酸性哮喘和严重哮喘的疾病中的疗效，我们完成了系统的疾病。在2019年2月的Embase，Medline，PubMed，Cochrane库，ClinicalTrials.gov和先前系统评价的参考列表中。我们包括平行组，双盲，随机对照试验的成年人，比较至少8周的Azithromycin治疗与安慰剂，在至少6个月内评估了加重的结果。从已发布的来源中提取数据，应用了偏置工具的Cochrane风险，并从作者那里寻求IPD。审查是重复的。我们对恶化的主要结果进行了IPD荟萃分析，并针对继发结果进行了随机效应荟萃分析。结果鉴定了三项研究（n = 604）。 In the IPD meta-analysis, treatment with azithromycin was associated with a reduced rate of exacerbations (oral corticosteroid course due to worsening asthma, antibiotic use for lower respiratory tract infection, hospitalisation and/or emergency department visits) in asthma as well as in the noneosinophilic, eosinophilic and severe asthma subgroups. Examining each exacerbation type separately, patients with eosinophilic asthma reported fewer oral corticosteroid courses, and patients with noneosinophilic and severe asthma reported fewer antibiotic courses. Azithromycin was well tolerated.Discussion Maintenance use of azithromycin reduces exacerbations in patients with eosinophilic, noneosinophilic and severe asthma.Maintenance use of azithromycin in conjunction with existing maintenance asthma treatment reduces exacerbations in severe asthma, eosinophilic asthma and noneosinophilic asthma http://bit.ly/2m8mnIx ER -