TY-JUR T1 - 维护氮霉素是否会降低哮喘恶化？个人参与者数据Meta-Analysis JF - 欧洲呼吸期刊Jo - Eur Respir J Do - 10.1183 / 13993003.01381-2019 VL - 54是 - 5 SP - 1901381 Au - Hiles，Sarah A. Au - 麦当劳，Vanessa M. Au - Guilhermino - Guilhermino，Michelle Au - Brusselle，Guy G. Au - Gibson，Peter G. Y1 - 2019/11/01 UR - //www.qdcxjkg.com/content/54/5/1901381.abstract n2 - 防止加剧的背景哮喘治疗的重要目标。用氮霉素的长期治疗可能有助于实现这一目标。我们的目的是进行系统审查和个人参与者数据（IPD）荟萃分析，以检查阿奇霉素在哮喘中降低恶化的疗效，并在非聚糖哮喘，嗜酸性哮喘和严重哮喘的副术中。我们完成了系统搜索Embase，Medline，Pubmed，Cochrane图书馆，Clinicaltrials.gov及之前的系统评论的参考列表在2019年2月。我们包括在成人中的平行组，双盲，随机对照试验，比较至少8周的Aitithromycin治疗与安慰剂，在8个月内评估加剧结果的结果。数据从已发表的来源提取，应用偏置工具的Cochrane风险，并从作者中寻找IPD。评论是重复的。我们对IPD Meta分析进行了加剧的主要结果，以及次要结果的随机效应Meta分析。鉴定了三项研究（n = 604）。 In the IPD meta-analysis, treatment with azithromycin was associated with a reduced rate of exacerbations (oral corticosteroid course due to worsening asthma, antibiotic use for lower respiratory tract infection, hospitalisation and/or emergency department visits) in asthma as well as in the noneosinophilic, eosinophilic and severe asthma subgroups. Examining each exacerbation type separately, patients with eosinophilic asthma reported fewer oral corticosteroid courses, and patients with noneosinophilic and severe asthma reported fewer antibiotic courses. Azithromycin was well tolerated.Discussion Maintenance use of azithromycin reduces exacerbations in patients with eosinophilic, noneosinophilic and severe asthma.Maintenance use of azithromycin in conjunction with existing maintenance asthma treatment reduces exacerbations in severe asthma, eosinophilic asthma and noneosinophilic asthma http://bit.ly/2m8mnIx ER -