Hyun % % 0期刊文章% Lee Ryu, Jiin %南,Eunwoo %一涌,唱小君%唷,Yoomi %公园,东%赢得了公园,大太阳%一个月亮,Ji-Yong %金,Tae-Hyung %孙,张成泽赢得% Yoon,何鸿燊Joo % Kim Sang-Heon % T corticosteroid-dependent哮喘患者死亡率增加:一项全国性的以人群为基础的研究:慢性系统性皮质类固醇(CS)治疗与许多慢性疾病患者的死亡风险增加有关。然而，慢性全身性CS治疗是否与哮喘患者的死亡率增加有关尚未阐明。本研究的目的是确定慢性全身性CS治疗对成人哮喘患者长期死亡率的影响。方法采用2005 - 2015年韩国国民健康保险服务数据库，对≥18岁哮喘患者进行人群配对队列研究。评估CS依赖组(CS在基线期间使用≥6个月)与CS独立组(CS在基线期间使用<6个月)患者全因死亡率的95%置信区间的危险比(HR)。结果基线队列包括466 941例哮喘患者，其中8334例为cs依赖，458 607例为cs独立。经1:1配对，确定8334名与cs无关的哮喘患者。与cs无关的哮喘相比，cs依赖性哮喘的死亡率HR为2.17 (95% CI 2.04-2.31)。在接受低剂量CS的患者中，HR为1.84 (95% CI 1.69-2.00);在接受高剂量CS的患者中，HR为2.56 (95% CI 2.35-2.80)。Conclusions In this real-world, clinical practice, observational study, chronic use of systemic CS was associated with increased risk of mortality in patients with asthma, with a significant dose–response relationship between systemic CS use and long-term mortality.Chronic use of systemic corticosteroid (CS) was associated with increased risk of mortality in patients with asthma, with a significant dose–response relationship between systemic CS use and long-term mortality http://bit.ly/2ku3ZJl %U //www.qdcxjkg.com/content/erj/54/5/1900804.full.pdf