Hyun @article {Lee1900804作者= {Lee和Ryu Jiin南,Eunwoo涌,唱小君和杨,Yoomi和公园,东赢了,公园,大太阳和月亮、Ji-Yong和金姆,Tae-Hyung孙,张成泽和尹,何鸿燊Joo和金姆,Sang-Heon}, title = {corticosteroid-dependent哮喘患者死亡率增加:全国性的以人群为基础的研究},体积= {54}= {5},elocation-id = {1900804} = {2019}, doi ={10.1183/13993003.00804 -2019},出版商={欧洲呼吸学会},文摘={介绍慢性系统性皮质类固醇(CS)治疗与患者死亡率的风险增加许多慢性疾病。188bet官网地址然而，慢性全身性CS治疗是否与哮喘患者的死亡率增加有关尚未阐明。本研究的目的是确定慢性全身性CS治疗对成人哮喘患者长期死亡率的影响。方法采用2005 - 2015年韩国国民健康保险服务数据库，对年龄为18岁的哮喘患者进行基于人群的配对队列研究。以95%置信区间(基线期间CS使用>=6个月)评估CS依赖队列与CS独立队列(基线期间CS使用<6个月)患者的全因死亡率的危险比(HR)。结果基线队列包括466 941例哮喘患者，其中8334例为cs依赖，458 607例为cs独立。经1:1配对，确定8334名与cs无关的哮喘患者。与cs非依赖性哮喘相关的死亡率HR为2.17 (95% CI 2.04{textendash}2.31)。在接受低剂量CS的患者中，HR为1.84 (95\% CI 1.69{\textendash}2.00);在接受高剂量CS的患者中，HR为2.56 (95\% CI 2.35{\textendash}2.80)。Conclusions In this real-world, clinical practice, observational study, chronic use of systemic CS was associated with increased risk of mortality in patients with asthma, with a significant dose{\textendash}response relationship between systemic CS use and long-term mortality.Chronic use of systemic corticosteroid (CS) was associated with increased risk of mortality in patients with asthma, with a significant dose{\textendash}response relationship between systemic CS use and long-term mortality http://bit.ly/2ku3ZJl}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/5/1900804}, eprint = {//www.qdcxjkg.com/content/54/5/1900804.full.pdf}, journal = {European Respiratory Journal} }