RT期刊文章SR电子T1他克莫司对机械和体液因素的影响大脑death-induced肺损伤摩根富林明欧洲呼吸杂志乔和J FD欧元欧洲呼吸学会SP PA3353做10.1183/13993003.国会- 2019。188bet官网地址PA3353 VO 54 5 63 A1 Belhaj, Asmae A1 Dewachter,劳伦斯A1 Mc Entee,凯萨琳A1 Naeije,罗伯特•A1 Rondelet Benoit年2019 UL //www.qdcxjkg.com/content/54/suppl_63/PA3353.abstract AB脑死亡的机制(BD)全身的肺损伤是由于机械和体液的扰动。脑死亡是由缓慢颅内血液注入麻醉诱导后猪随机安慰剂(n = 9)或他克莫司(n = 8;0.1毫克/公斤/ J)抑制促炎症介质的表达。肺动脉压(PAP),楔形PAP (PAWP),肺血管阻力(PVR)和有效的肺毛细管压力(PCP)测定2,4,6小时后库欣反射。肺组织病理检查采样来确定基因表达cytokinesand得分肺损伤。颅内高血压引起的瞬态增加血压后,被诊断为脑死亡后,在巴氏持续增加,卡式肺囊虫肺炎和PVR的静脉分量,而PAWP没有改变。动脉警察乙/分数启发O2 (PaO2 /供给)下降。脑死亡与中性粒细胞在肺组织的积累增加促炎白介素6 (IL) / IL - 10比值。血il - 6的表达和IL-1β也增加。血il - 6的表达和IL-1β也增加。他克莫司预处理与增加卡式肺囊虫肺炎和PVR静脉组件的削弱,回到基线BD 6小时后,部分肺组织纠正生物扰动。 PaO2/FiO2 and lung injury score were prevented.In conclusion, increase in pulmonary capillary pressure with pulmonary venous resistance, associated with lung inflammatory process were partially prevented by tacrolimus BD-induced lung injury pig model.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3353.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).