TY - JOUR T1 -他克莫司对脑死亡诱导肺损伤机械和体液决定因素的影响JF -欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.congress-2019。PA3353 VL - 54 IS - sul 63 SP - PA3353 AU - Belhaj, Asmae AU - Dewachter, Laurence AU - Mc Entee, Kathleen AU - Naeije, Robert AU - Rondelet, Benoit Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA3353.abstract N2 -脑死亡(BD)诱导的肺损伤机制是由于机械和体液扰动。将麻醉猪随机分为安慰剂组(n = 9)或他克莫司组(n = 8)，经缓慢颅内输血诱导脑死亡;0.1 mg/Kg/J)抑制促炎介质的表达。测定库欣反射后2、4、6 h肺动脉压(PAP)、楔形肺动脉压(PAWP)、肺血管阻力(PVR)和有效肺毛细血管压(PCP)。取肺组织样本，测定细胞因子基因表达，病理评分肺损伤。颅内高压引起血压短暂性升高，在脑死亡诊断后，PAP、PCP和PVR的静脉成分持续升高，而PAWP没有变化。动脉血氧饱和度(PO2/ PaO2/FiO2)降低。脑死亡与肺组织中性粒细胞积聚以及促炎白细胞介素(IL)-6/IL-10比值升高有关。IL-6和IL-1β的血液表达也升高。IL-6和IL-1β的血液表达也升高。他克莫司预处理与PCP和PVR静脉组分增加的钝化相关，在BD后6小时恢复到基线，并部分纠正肺组织生物学扰动。 PaO2/FiO2 and lung injury score were prevented.In conclusion, increase in pulmonary capillary pressure with pulmonary venous resistance, associated with lung inflammatory process were partially prevented by tacrolimus BD-induced lung injury pig model.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3353.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -