TY - JOUR T1 -循环microRNAs可识别社区获得性肺炎内源性JF - European Respiratory Journal JO - Eur Respir J DO - 10.1183/13993003.congress-2019。PA5449 VL - 54 IS -补充63 SP - PA5449 AU - Sanz Herrero，弗朗西斯科AU - Vicente Ferrer，西尔维亚AU -布里奥内斯，María路易莎AU - Martínez，马塞利诺AU -洛萨达，杰西卡AU - Fernández法贝拉斯，埃斯特雷拉AU - Aibar，阿拉塞利AU -费雷尔，桑托斯AU - Dasí Fernández，弗朗西斯科Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA5449.abstract N2 -背景:在社区获得性肺炎(CAP)患者中，特别是在那些出现严重并发症的患者中，识别宿主过程失调可能对这种疾病的未来管理至关重要。我们的目标是通过研究microRNAs谱来定义与并发症相关的不同CAP内源性型。方法:对连续住院CAP病例进行观察性前瞻性研究。采用qRT-PCR分析循环microRNAs。我们研究了miRNAs与严重脓毒症和急性低氧性呼吸衰竭的相关性和预测价值(AHRF: PaO2/FiO2<250)。结果:我们分析了169例CAP患者的临床资料和血液样本。平均年龄66.9岁(IQR: 58 ~ 79)。主要合并症为糖尿病(29%)、慢性阻塞性肺病(28.4%)、心律失常(13.6%)和脑血管疾病(8.9%)。97例(57.4%)患者表现为重度CAP (PSI IV-V)。 Complications were found in 109 patients (64.5%): AHRF was present in 25.4%, and severe sepsis in 13.6%. Mortality was 3.6%. We found that miR 223 and miR 574 were downregulated in severe sepsis (AUC 0.78), and in AHRF (AUC 0.77) respectively. miR 182 downregulation had a high predictive value to predict both severe sepsis and AHRF (AUC 0.83 and 0.76) in hospitalized CAP patients.Conclusions: 1-We have identified different endotypes in CAP determined by circulating miRNAs profiles.2-The expression of miR-223, miR-574, and miR-182 are related to severe sepsis and AHRF in hospitalized CAP patients.Funded by: Sociedad Valenciana de NeumologíaFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5449.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -