TY -的T1 -循环小分子核糖核酸可以识别endotypes摩根富林明社区获得性肺炎——欧洲呼吸杂志》乔——欧元和J - 10.1183/13993003.国会- 2019。PA5449六世- 54 - 5 63 SP - PA5449盟Sanz Herrero弗朗西斯科AU -韦森特费雷尔,西尔维亚AU - Briones,玛丽亚·路易萨盟-马丁内斯,Marcelino盟——镇压,杰西卡AU -费尔南德斯这个婴儿,爱丝特雷娜AU - Aibar,婀瑞思利AU -费雷尔,桑托斯盟便费尔南德斯,旧金山Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA5449.abstract N2 -背景:识别宿主过程中特异表达的社区获得性肺炎(CAP)的患者,尤其是在那些发展严重的并发症可能为未来的这种疾病的管理是至关重要的。我们的目标是研究小分子核糖核酸概要文件定义不同的帽子endotypes有关的并发症。方法:一项观察连续帽住院病例的前瞻性研究。循环使用中存在小分子核糖核酸进行了分析。我们研究的相关性和预测价值microrna在严重脓毒症和急性血氧过低的呼吸衰竭(AHRF: PaO2 / FiO2< 250)。结果:我们分析了临床数据和169限制患者的血液样本。的平均年龄为66.9岁(IQR: 58 - 79)。主要并发症是糖尿病(29%),慢性阻塞性肺病(28.4%)、心律失常(13.6%),脑血管疾病(8.9%)。97名患者(57.4%)出现严重帽(ψIV-V)。并发症被发现在109名患者(64.5%):AHRF存在于25.4%,严重脓毒症的13.6%。 Mortality was 3.6%. We found that miR 223 and miR 574 were downregulated in severe sepsis (AUC 0.78), and in AHRF (AUC 0.77) respectively. miR 182 downregulation had a high predictive value to predict both severe sepsis and AHRF (AUC 0.83 and 0.76) in hospitalized CAP patients.Conclusions: 1-We have identified different endotypes in CAP determined by circulating miRNAs profiles.2-The expression of miR-223, miR-574, and miR-182 are related to severe sepsis and AHRF in hospitalized CAP patients.Funded by: Sociedad Valenciana de NeumologíaFootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5449.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -