TY - JOUR T1 - effect of a mobile HFCWO device for气道间隙:impact on hyperinflationPA4528六世- 54 - 5 63 SP - PA4528盟Leemans Glenn AU - De Hondt Annelies AU - ide,克丽丝AU - Van Holsbeke,塞德里克盟——Belmans丹尼斯AU -贝克尔,布莱恩AU - Van Hoorenbeeck,金正日Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA4528.abstract N2 -简介:高频胸壁振荡(HFCWO)是囊性纤维化(CF)患者常用的气道清除技术(ACT)。然而，HFCWO设备的可用性依赖于交流电源。本研究旨在评估一种新型移动HFCWO设备(mHFCWO) (Monarch®系统)的有效性。方法:这是一项随机、开放、交叉研究。受试者被随机分配到mHFCWO或标准非移动式HFCWO设备(sHFCWO) (The Vest®System)。治疗时间为30分钟，在每个设备上设置多个频率和强度。受试者在治疗30分钟和治疗后1小时收集痰液。在治疗前和收集痰液后分别进行肺量测定和HRCT扫描。布罗迪评分和功能呼吸成像(FRI)用于评估肺状态和气道几何形状。结果:8例稳定的CF患者完成本研究。 Mean wet sputum weight and spirometry parameters were similar between mHFCWO and sHFCWO (figure1). Brody scores showed statistically significant improvement after therapy with mHFCWO (figure1). Additionally, FRI showed statistically significant differences in airway geometry and patency (siVaw/siRaw) suggesting mucus shifting with a reduction in regional lobar volume (iVlobe)-(figure1).Conclusion: mHFCWO (Monarch® System) provides effective ACT in CF patients with a shift in mucus and a reduction in hyperinflation.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4528.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -