作者@article {LeemansPA4528 = {Leemans,格伦and De Hondt, Annelies and Ides, Kris and Van Holsbeke, Cedric and Belmans, Dennis and Becker, Brian and Van Hoorenbeeck, Kim}, title = {Effectiveness of a mobile HFCWO device for airway clearance: impact on hyperinflation}, volume = {54}, number = {suppl 63}, elocation-id = {PA4528}, year = {2019}, doi = {10.1183/13993003.congress-2019.PA4528}, publisher = {European Respiratory Society}, abstract = {Introduction: High frequency chest wall oscillation (HFCWO) is a commonly used airway clearance technique (ACT) in patients with Cystic Fibrosis (CF). However, the usability of an HFCWO device is dependent on an AC power source. This study aimed to assess effectiveness of a new mobile HFCWO device (mHFCWO) (Monarch{\textregistered} System).Methodology: This was a randomized, open-label, crossover study. Subjects were randomized to mHFCWO or standard non-mobile HFCWO device (sHFCWO) (The Vest{\textregistered} System). Treatments were 30 minutes with multiple frequencies and intensity settings on each device. Subjects collected sputum during 30-minute therapy and one-hour post-therapy. Spirometry and HRCT scans were done before therapy and after sputum collection. Brody scores and Functional respiratory imaging (FRI) were used to evaluate lung status and airway geometry.Results: 8 stable CF patients completed the study. Mean wet sputum weight and spirometry parameters were similar between mHFCWO and sHFCWO (figure1). Brody scores showed statistically significant improvement after therapy with mHFCWO (figure1). Additionally, FRI showed statistically significant differences in airway geometry and patency (siVaw/siRaw) suggesting mucus shifting with a reduction in regional lobar volume (iVlobe)-(figure1).Conclusion: mHFCWO (Monarch{\textregistered} System) provides effective ACT in CF patients with a shift in mucus and a reduction in hyperinflation.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4528.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).}, issn = {0903-1936}, URL = {//www.qdcxjkg.com/content/54/suppl_63/PA4528}, eprint = {//www.qdcxjkg.com/content}, journal = {European Respiratory Journal} }