在一项以人群为基础的汉族队列研究中，RAGE基因多变异与哮喘和COPD风险的关联PA5396六世- 54 - 5 63 SP - PA5396盟妞妞Hongtao AU -杨,Ting盟——妞妞,温泉盟——黄,柯盟——段Ruirui AU - Yu道盟——王、陈Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/PA5396.abstract N2 -背景:虽然一些研究评估了晚期糖基化终末产物(RAGE)受体遗传变异与哮喘和COPD的关系，但结果仍然不一致。在一项以人群为基础的中国汉族队列研究中，我们旨在研究RAGE基因的多个变异与哮喘和慢性阻塞性肺病风险的关系，单独或联合。方法:采用TaqMan方法对347例哮喘或COPD患者和527例年龄和性别匹配的对照组进行RAGE基因rs1800625、rs1800624、rs2070600、rs184003和rs2071288的5个变异进行基因分型。数据采用Haplo进行分析。统计程序，并创建了nomogram哮喘和COPD风险预测模型。结果:5个突变体的基因型分布符合Hardy-Weinberg平衡。单基因座分析显示rs1800625在COPD中的等位基因分布与rs1800624在哮喘中的等位基因分布有统计学差异。单倍型分析表明，单倍型为T-A-G-T-G(依次为rs1800625、rs1800624、rs2070600、rs184003和rs2071288) (Padj。 = 0.0134) and T-A-A-G-G (P adj. = 0.0040) conferred a decrease risk for COPD and asthma respectively. Haplotype-phenotype analysis indicated significant association of high- and low-density lipoprotein cholesterol and blood urea nitrogen with COPD and total cholesterol with asthma (Psim < 0.05). Finally, two nomogram models were developed for predicting the risk of asthma and COPD, with descent accuracies.Conclusions: Our findings indicate that RAGE gene is a candidate gene in susceptibility to the development of asthma and COPD in Han Chinese.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5396.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -