TY - JOUR T1 -支气管内瓣膜对严重肺气肿患者预后的影响-欧洲呼吸杂志JO - Eur Respir J DO - 10.1183/13993003.congress-2019。RCT447六世- 54 - 5 63 SP - RCT447盟Dransfield马克AU - Bhatt,阿里亚盟——Slebos Dirk-Jan盟——Klooster Karin盟——Sciurba弗兰克AU -沙阿,Pallav AU -加纳,贾斯汀盟——Radhakrishnan Sri盟——Shargill Narinder AU -马,Nathaniel盟。克里内,杰拉德Y1 - 2019/09/28 UR - //www.qdcxjkg.com/content/54/suppl_63/RCT447.abstract N2 -简介:使用Zephyr®瓣膜的支气管镜肺减容术(BLVR)可以改善肺功能、运动耐受性和生活质量。在这里，我们报告进一步分析了解放研究中BLVR对患者报告结果(PROs)的影响。方法:在24个中心，190名严重异质性肺气肿患者随机分为2∶1 (Zephyr Valve to Standard of Care (SOC))。受试者53%为女性，平均用力呼气量(FEV1)预测为27.4%;预测残气量225%;圣乔治呼吸问卷(SGRQ) 54.5分;COPD评估试验(CAT)得分19.2分。比较了西风之神瓣膜组和SOC组的SGRQ、CAT总评分和单项评分以及12个月时过渡呼吸困难指数(TDI)的局灶评分和单项评分的改善情况。结果:与SoC患者相比，所有3个优点在Zephyr瓣膜患者中均有统计学意义和临床意义的改善(SGRQ， -7.05分; CAT, -3.1 points; TDI Focal score, 4.3 points). The improvement in the SGRQ was driven by the “Impacts” and “Activity” domains (p<0.05, and p<0.001, respectively; Figure 1). Improvements in CAT were driven by improvements in breathlessness (p<0.05), chest tightness (p<0.05), energy level (p<0.05), activities (p<0.001) and more confidence when leaving home (p<0.05). All three TDI measures of effort, task and functional impairment were improved (p<0.001).Conclusion: Data from the LIBERATE trial demonstrates that the Zephyr Valve significantly improves multidimensional measures of dyspnea and quality of life.FootnotesCite this article as: European Respiratory Journal 2019; 54: Suppl. 63, RCT447.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only). ER -